This preliminary report details the results of looking for pathway enrichment in each of the groups of genes produced by hierarchical clustering of the drug perturbations. I’ve cut the the data into 20, but this value can be changed if we decide on a different value. Otherwise, this analysis focuses on enriched pathways in the KEGG database. Specifically, this analysis uses the C2 KEGG segment from: https://www.gsea-msigdb.org/gsea/msigdb.
As for this report, the panel on the left is sorted by the number of dark kinases in the cluster and displays both the number of pathway hits and dark kinases in the cluster. The number of each cluster is arbitrary. The entry for each cluster displays the kinases associated with the cluster along with the number of non-kinases genes. Below this table are the pathways that passed the enrichment analysis at the 0.01 false discovery rate level. I also corrected for running this analysis for all 20 clusters.
Overall, 92 pathways are enriched in at least one of the following clusters. Of these pathways 60 are only hit once. The following pathways are seen in two or more clusters:
| gene_type | info |
|---|---|
| Dark Kinase (19) | CAMK1D, CAMKV, CDKL3, DYRK1B, LMTK2, LMTK3, MAP3K15, MAPK15, MARK1, MKNK1, NEK5, PIK3C2B, PIP5K1B, SBK1, SCYL2, STK3, TESK2, TSSK1B, VRK3 |
| Light Kinase (46) | ACVR1C, ACVR2A, ACVRL1, ANKK1, BMP2K, BMX, CAMK2B, CAMK4, CDK9, CSF1R, DAPK1, DAPK2, DCLK1, EPHA6, EPHB2, EPHB3, FGFR1, FGFR2, FGFR3, FGFR4, FLT4, HCK, ITK, JAK2, KALRN, KSR1, KSR2, MAP2K3, MAP2K6, MAP4K1, MAPK10, MAPK11, MAST1, MATK, PI4KAP2, PRKCG, PRKCZ, PRKD2, PTK2, RPS6KA3, SGK2, SRPK2, STK26, STYK1, TAF1L, TXK |
| Non-kinase Count | 1748 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_CELL_ADHESION_MOLECULES_CAMS | 0.0e+00 | 0.0e+00 | 1813 | 133 | 32 | CD22,CD34,CD40,CD6,CD86,CDH1,CDH15,CDH2,CDH3,CLDN10,CLDN23,CNTN1,ESAM,HLA-DPB1,ICAM2,ITGA6,ITGAL,ITGAM,ITGB7,JAM3,NCAM1,NECTIN2,NEO1,NFASC,NRXN1,NRXN2,NRXN3,OCLN,SELL,SELPLG,SPN,VCAN |
| KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 0.0e+00 | 0.0e+00 | 1813 | 272 | 42 | ADCYAP1R1,ADRA1A,AVPR1A,CHRM4,CHRNA10,CHRNA7,CHRNB2,CHRNB4,DRD2,DRD4,FPR2,GABRA1,GABRA6,GABRB2,GABRD,GABRP,GABRQ,GHR,GLRA3,GRID1,GRIK4,GRIK5,GRIN1,GRM7,HTR2A,LTB4R2,MC2R,NMUR1,NPFFR1,NPFFR2,NPY1R,OPRD1,OPRK1,P2RX7,P2RY1,P2RY8,PTAFR,PTGER4,S1PR3,S1PR5,SSTR2,VIPR2 |
| KEGG_MAPK_SIGNALING_PATHWAY | 0.0e+00 | 0.0e+00 | 1813 | 267 | 35 | CACNA1G,CACNA1I,CACNA2D1,CACNA2D2,CACNB2,CACNG7,CHP2,DUSP1,DUSP9,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FGFR4,GRB2,IL1R2,JUN,MAP2K3,MAP2K6,MAP4K1,MAPK10,MAPK11,MAPK8IP1,MAPK8IP2,MKNK1,NFATC4,PLA2G2D,PLA2G4A,PLA2G4E,PRKCG,RASGRF1,RPS6KA3,STK3 |
| KEGG_REGULATION_OF_ACTIN_CYTOSKELETON | 0.0e+00 | 2.0e-07 | 1813 | 213 | 28 | ACTN2,APC2,CFL2,CHRM4,CYFIP2,ENAH,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FGFR4,ITGA6,ITGAL,ITGAM,ITGAX,ITGB7,MYH14,MYL2,NCKAP1L,PIK3R5,PIP4K2A,PIP5K1B,PTK2,SCIN,VAV1,WAS |
| KEGG_CALCIUM_SIGNALING_PATHWAY | 0.0e+00 | 3.0e-07 | 1813 | 177 | 25 | ADCY4,ADRA1A,ATP2A3,ATP2B2,AVPR1A,CACNA1G,CACNA1I,CAMK2B,CAMK4,CD38,CHP2,CHRNA7,GNAL,GRIN1,HTR2A,LTB4R2,NOS1,NOS2,P2RX7,PDE1B,PLCD1,PRKCG,PTAFR,RYR1,RYR3 |
| KEGG_AXON_GUIDANCE | 0.0e+00 | 3.0e-07 | 1813 | 129 | 21 | CFL2,CHP2,DCC,DPYSL5,EFNA2,EPHA6,EPHB2,EPHB3,LRRC4C,NCK2,NFATC4,NTN1,PTK2,ROBO1,SEMA4D,SEMA5B,SEMA7A,SLIT1,SLIT3,SRGAP3,UNC5B |
| KEGG_TIGHT_JUNCTION | 3.0e-07 | 8.6e-06 | 1813 | 132 | 19 | ACTN2,CGN,CLDN10,CLDN23,IGSF5,JAM3,MAGI2,MYH14,MYH15,MYL2,OCLN,PARD6G,PPP2R2C,PRKCG,PRKCZ,RAB3B,SPTAN1,SYMPK,TJP1 |
| KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 5.0e-07 | 1.2e-05 | 1813 | 265 | 28 | ACVR2A,ACVRL1,CCL26,CCR6,CD40,CD70,CSF1R,CX3CR1,CXCR2,EDA,FLT4,GHR,IFNLR1,IL11,IL12A,IL19,IL1R2,IL23R,IL2RB,IL3RA,IL7,INHBB,INHBC,NGFR,TNFRSF19,TNFRSF8,TNFSF10,TNFSF15 |
| KEGG_O_GLYCAN_BIOSYNTHESIS | 8.0e-07 | 1.6e-05 | 1813 | 30 | 9 | B4GALT5,GALNT10,GALNT13,GALNT16,GALNT6,GALNT9,GCNT3,GCNT4,ST3GAL2 |
| KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION | 1.0e-06 | 1.9e-05 | 1813 | 116 | 17 | ACTN2,CLDN10,CLDN23,CYBB,ESAM,ITGAL,ITGAM,ITK,JAM3,MAPK11,MYL2,OCLN,PIK3R5,PRKCG,PTK2,TXK,VAV1 |
| KEGG_PATHWAYS_IN_CANCER | 3.4e-06 | 5.8e-05 | 1813 | 325 | 30 | APC2,CBL,CDH1,CDKN2A,CEBPA,CSF1R,DAPK1,DAPK2,DCC,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FZD9,GLI1,GRB2,ITGA6,JUN,LAMA4,MAPK10,NKX3-1,NOS2,PIK3R5,PRKCG,PTK2,RARB,TCF7,TCF7L1 |
| KEGG_CARDIAC_MUSCLE_CONTRACTION | 4.4e-06 | 6.8e-05 | 1813 | 78 | 13 | ATP1A3,ATP1B1,ATP1B2,CACNA2D1,CACNA2D2,CACNB2,CACNG7,COX6B2,COX7B2,MYL2,TNNI3,TNNT2,UQCRHL |
| KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY | 1.0e-05 | 1.5e-04 | 1813 | 137 | 17 | CHP2,GRB2,ICAM2,ITGAL,KLRC1,KLRC3,NFATC4,PIK3R5,PRKCG,RAET1G,SH2D1A,SHC4,TNFSF10,ULBP1,ULBP2,ULBP3,VAV1 |
| KEGG_HEMATOPOIETIC_CELL_LINEAGE | 1.5e-05 | 2.0e-04 | 1813 | 87 | 13 | CD1D,CD22,CD34,CD38,CD3D,CR2,CSF1R,IL11,IL1R2,IL3RA,IL7,ITGA6,ITGAM |
| KEGG_LONG_TERM_DEPRESSION | 4.2e-05 | 4.8e-04 | 1813 | 70 | 11 | GNAO1,GNAZ,GUCY1A1,GUCY1A2,GUCY1B1,NOS1,PLA2G2D,PLA2G4A,PLA2G4E,PRKCG,RYR1 |
| KEGG_TYPE_II_DIABETES_MELLITUS | 4.2e-05 | 4.8e-04 | 1813 | 47 | 9 | ABCC8,CACNA1G,KCNJ11,MAFA,MAPK10,PIK3R5,PRKCZ,SLC2A4,SOCS4 |
| KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 4.4e-05 | 4.8e-04 | 1813 | 96 | 13 | CFL2,HCK,MYO10,PIK3R5,PIP5K1B,PLA2G4A,PLA2G4E,PLPP2,PRKCG,SCIN,VAV1,WAS,WASF3 |
| gene_type | info |
|---|---|
| Dark Kinase (16) | CDK11A, CDK12, CDK17, CDKL1, CLK3, COQ8A, CSNK1G1, CSNK2A2, DYRK2, HIPK1, NEK7, PDIK1L, RIOK3, SCYL1, STK19, TLK2 |
| Light Kinase (41) | ABL2, ARAF, ATM, AURKB, BRD4, BTK, BUB1, CAMK2G, CDK1, CDK2, CHEK1, CLK1, DGKZ, FER, GRK7, GSK3A, GTF2F1, HKDC1, IRAK3, LYN, MAP2K7, MAP4K4, MAPK6, MAPK8, MASTL, MELK, MYLK2, NEK2, PAK1, PAK2, PLK4, RPS6KA5, SIK1, SIK1B, SMG1, SRPK1, STK10, STK35, TYRO3, WEE1, YES1 |
| Non-kinase Count | 1873 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_SPLICEOSOME | 0.0e+00 | 0.0e+00 | 1930 | 127 | 39 | ALYREF,BCAS2,CDC40,CHERP,HNRNPA1,HNRNPA3,HNRNPK,HNRNPU,HSPA6,HSPA8,ISY1,LSM8,MAGOHB,PHF5A,PQBP1,PRPF18,PRPF38A,PUF60,RBM17,RBM22,RBM25,RBM8A,RBMX,SART1,SF3A2,SF3A3,SF3B2,SLU7,SNRPA,SNRPA1,SNRPB,SNW1,SRSF4,SYF2,TCERG1,THOC1,U2SURP,WBP11,XAB2 |
| KEGG_PROTEASOME | 0.0e+00 | 0.0e+00 | 1930 | 46 | 20 | POMP,PSMA1,PSMA2,PSMA3,PSMA7,PSMB2,PSMB5,PSMB6,PSMB7,PSMC1,PSMC2,PSMC3,PSMC4,PSMC6,PSMD1,PSMD12,PSMD2,PSMD6,PSMD8,PSME2 |
| KEGG_RNA_DEGRADATION | 0.0e+00 | 0.0e+00 | 1930 | 59 | 20 | C1D,CNOT10,CNOT2,CNOT3,CNOT4,CNOT6,CNOT6L,CNOT9,DCP1A,DCP2,DIS3,EXOSC10,EXOSC3,EXOSC4,EXOSC5,EXOSC9,HSPA9,LSM8,PAPOLA,TENT4A |
| KEGG_CELL_CYCLE | 0.0e+00 | 0.0e+00 | 1930 | 124 | 27 | ATM,BUB1,CCNA2,CCNB1,CCNB2,CDC16,CDC25A,CDC25C,CDC27,CDC6,CDK1,CDK2,CHEK1,CREBBP,CUL1,E2F3,ESPL1,MCM7,ORC6,RAD21,SFN,SMAD4,SMC1B,STAG1,STAG2,TFDP2,WEE1 |
| KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS | 0.0e+00 | 0.0e+00 | 1930 | 134 | 27 | CDC16,CDC27,COP1,CUL1,CUL3,CUL4A,DDB1,ERCC8,FBXO2,FBXW11,ITCH,PML,RCHY1,RNF7,SMURF1,TRIP12,UBA2,UBA6,UBE2A,UBE2C,UBE2D3,UBE2I,UBE2K,UBE2M,UBE2Z,UBE3A,XIAP |
| KEGG_OOCYTE_MEIOSIS | 0.0e+00 | 0.0e+00 | 1930 | 112 | 22 | BUB1,CAMK2G,CCNB1,CCNB2,CDC16,CDC25C,CDC27,CDK1,CDK2,CPEB1,CUL1,ESPL1,FBXW11,ITPR3,PPP2CB,PPP2R1B,PPP2R5D,PPP2R5E,PPP3CC,PPP3R1,SMC1B,SPDYA |
| KEGG_HUNTINGTONS_DISEASE | 0.0e+00 | 2.0e-07 | 1930 | 180 | 26 | AP2B1,ATP5F1B,ATP5PB,CASP3,CLTA,CLTB,CLTC,COX5A,CREB1,CREBBP,CYC1,DCTN4,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,NRF1,POLR2J2,SLC25A5,SOD1,TBPL2,UQCRC2,UQCRH,VDAC1,VDAC2 |
| KEGG_APOPTOSIS | 2.0e-07 | 4.7e-06 | 1930 | 87 | 16 | ATM,BID,CAPN2,CASP10,CASP3,CASP7,DFFB,EXOG,IRAK3,NFKB1,PPP3CC,PPP3R1,TNFRSF10A,TNFRSF10D,TRAF2,XIAP |
| KEGG_ALZHEIMERS_DISEASE | 1.8e-06 | 3.6e-05 | 1930 | 165 | 21 | APH1A,ATP5F1B,ATP5PB,BID,CAPN2,CASP3,CASP7,COX5A,CYC1,HSD17B10,ITPR3,NAE1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,PPP3CC,PPP3R1,UQCRC2,UQCRH |
| KEGG_PROTEIN_EXPORT | 2.1e-06 | 3.8e-05 | 1930 | 24 | 8 | SEC11A,SEC61A2,SEC62,SEC63,SPCS2,SRP72,SRP9P1,SRPRB |
| KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION | 4.5e-06 | 7.6e-05 | 1930 | 85 | 14 | ARAF,BUB1,CCNA2,CCNB1,CCNB2,CDC16,CDC25A,CDC25C,CDC27,CDK1,CDK2,CPEB1,MAPK8,SPDYA |
| KEGG_ENDOCYTOSIS | 7.7e-06 | 1.2e-04 | 1930 | 181 | 21 | ACAP2,AP2B1,CHMP4B,CHMP5,CLTA,CLTB,CLTC,DNM2,GRK7,HGS,HSPA6,HSPA8,ITCH,PARD3,RAB11FIP2,RBSN,SH3KBP1,SMURF1,STAM,VPS37A,VPS4A |
| KEGG_P53_SIGNALING_PATHWAY | 1.0e-05 | 1.5e-04 | 1930 | 68 | 12 | ATM,BID,CASP3,CCNB1,CCNB2,CDK1,CDK2,CHEK1,COP1,MDM4,RCHY1,SFN |
| KEGG_WNT_SIGNALING_PATHWAY | 2.1e-05 | 2.8e-04 | 1930 | 150 | 18 | AXIN1,CAMK2G,CREBBP,CSNK2A2,CTBP2,CUL1,DVL3,FBXW11,MAPK8,PPP2CB,PPP2R1B,PPP2R5D,PPP2R5E,PPP3CC,PPP3R1,SMAD4,TCF7L2,WNT9B |
| KEGG_PARKINSONS_DISEASE | 3.6e-05 | 4.5e-04 | 1930 | 128 | 16 | ATP5F1B,ATP5PB,CASP3,COX5A,CYC1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,SLC25A5,UBB,UQCRC2,UQCRH,VDAC1,VDAC2 |
| gene_type | info |
|---|---|
| Dark Kinase (14) | CDK19, DSTYK, HIPK3, LRRK1, MAP3K10, MARK4, NEK11, PIP4K2C, PIP5K1C, RPS6KC1, SBK3, SRPK3, STK38L, TTBK2 |
| Light Kinase (32) | AAK1, ABR, ACVR1, BRD2, CAMK2D, CSNK1D, DGKD, EIF2AK3, FRK, GSK3B, HK1, ILK, INSR, JAK1, LATS2, MAP2K2, MAP3K8, MAPK1, MAPKAPK2, MST1R, MYLK3, MYLK4, NRBP1, NUAK1, PEAK1, PI4K2A, PINK1, SIK3, TAOK3, TGFBR1, TRPM7, ULK1 |
| Non-kinase Count | 1183 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_LYSOSOME | 0.0e+00 | 0.0e+00 | 1229 | 121 | 25 | ATP6AP1,CD164,CD63,CLN3,CLTCL1,CTNS,CTSA,CTSB,CTSD,CTSF,DNASE2,GAA,GALNS,GNS,IGF2R,LAMP2,MANBA,MCOLN1,NEU1,PLA2G15,PSAP,SCARB2,SLC17A5,SMPD1,TPP1 |
| KEGG_REGULATION_OF_ACTIN_CYTOSKELETON | 0.0e+00 | 0.0e+00 | 1229 | 213 | 28 | ACTG1,ARHGEF12,ARHGEF6,ARPC3,BAIAP2,CDC42,CRK,CYFIP1,FGF13,IQGAP1,ITGA1,ITGA7,ITGAV,ITGB1,MAP2K2,MAPK1,MSN,MYL12A,MYL12B,MYL5,MYLK3,PIP4K2C,PIP5K1C,RHOA,RRAS,RRAS2,TIAM2,WASL |
| KEGG_FOCAL_ADHESION | 0.0e+00 | 0.0e+00 | 1229 | 199 | 25 | ACTG1,ARHGAP5,CDC42,COL11A2,COL6A1,COL6A2,CRK,CTNNB1,GSK3B,HGF,ILK,ITGA1,ITGA7,ITGAV,ITGB1,LAMC1,MAPK1,MYL12A,MYL12B,MYL5,MYLK3,PIP5K1C,RAPGEF1,RHOA,THBS3 |
| KEGG_STEROID_BIOSYNTHESIS | 0.0e+00 | 0.0e+00 | 1229 | 17 | 9 | CYP51A1,DHCR24,EBP,FDFT1,LSS,MSMO1,NSDHL,SC5D,SOAT1 |
| KEGG_PATHWAYS_IN_CANCER | 2.0e-07 | 6.6e-06 | 1229 | 325 | 26 | ARNT,ARNT2,CCDC6,CDC42,CRK,CSF2RA,CTNNA1,CTNNB1,FGF13,FZD8,GSK3B,HGF,ITGAV,ITGB1,JAK1,LAMC1,MAP2K2,MAPK1,NCOA4,PAX8,RALGDS,RHOA,STAT5B,TGFBR1,TRAF6,WNT5B |
| KEGG_ADHERENS_JUNCTION | 2.0e-07 | 6.6e-06 | 1229 | 73 | 12 | ACTG1,BAIAP2,CDC42,CTNNA1,CTNNB1,INSR,IQGAP1,MAPK1,RHOA,SORBS1,TGFBR1,WASL |
| KEGG_ENDOCYTOSIS | 6.0e-07 | 1.7e-05 | 1229 | 181 | 18 | ARAP1,ASAP2,CDC42,CHMP1B,CHMP2A,CLTCL1,CXCR4,DAB2,EPS15,GIT2,MVB12B,PIP5K1C,PSD4,RAB11FIP5,RAB31,RAB5B,SH3GLB1,TRAF6 |
| KEGG_AXON_GUIDANCE | 7.0e-07 | 1.7e-05 | 1229 | 129 | 15 | ARHGEF12,CDC42,CHP1,CXCR4,EFNA1,EFNB3,GNAI2,GSK3B,ITGB1,MAPK1,NFAT5,PLXNA3,RHOA,SEMA4B,SEMA6C |
| KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS | 9.0e-07 | 1.9e-05 | 1229 | 15 | 6 | ACAT1,ACAT2,FDPS,HMGCR,HMGCS1,IDI1 |
| KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION | 1.1e-06 | 2.0e-05 | 1229 | 116 | 14 | ACTG1,ARHGAP5,CDC42,CTNNA1,CTNNB1,CXCR4,GNAI2,ITGB1,MSN,MYL12A,MYL12B,MYL5,NCF2,RHOA |
| KEGG_TIGHT_JUNCTION | 5.1e-06 | 8.6e-05 | 1229 | 132 | 14 | ACTG1,CDC42,CTNNA1,CTNNB1,EXOC3,EXOC4,GNAI2,MYL12A,MYL12B,MYL5,PATJ,RHOA,RRAS,RRAS2 |
| KEGG_FATTY_ACID_METABOLISM | 7.3e-06 | 1.1e-04 | 1229 | 42 | 8 | ACAT1,ACAT2,ACOX1,ACSL1,ADH5,EHHADH,HADHA,HADHB |
| KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION | 8.5e-06 | 1.2e-04 | 1229 | 56 | 9 | ACTG1,ARPC3,CDC42,CTNNB1,ITGB1,LY96,RHOA,WASL,YWHAZ |
| KEGG_ALZHEIMERS_DISEASE | 1.6e-05 | 2.1e-04 | 1229 | 165 | 15 | ADAM17,APP,CAPN1,CHP1,COX6A1,COX6C,EIF2AK3,GRIN2D,GSK3B,ITPR2,LRP1,MAPK1,MT-ATP6,MT-ATP8,PSEN1 |
| KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION | 2.8e-05 | 3.5e-04 | 1229 | 115 | 12 | ADCY2,ARHGEF12,CALCRL,CALD1,GNAS,ITPR2,MAP2K2,MAPK1,MYL6,MYL6B,MYLK3,RHOA |
| KEGG_ECM_RECEPTOR_INTERACTION | 4.1e-05 | 4.8e-04 | 1229 | 84 | 10 | COL11A2,COL6A1,COL6A2,ITGA1,ITGA7,ITGAV,ITGB1,LAMC1,SDC2,THBS3 |
| KEGG_TGF_BETA_SIGNALING_PATHWAY | 4.6e-05 | 5.0e-04 | 1229 | 85 | 10 | ACVR1,DCN,MAPK1,RHOA,SKP1,SMAD7,SMAD9,TGFBR1,THBS3,ZFYVE16 |
| gene_type | info |
|---|---|
| Dark Kinase (13) | ALPK3, CDC42BPB, CDK15, CDKL5, ICK, NEK10, NEK8, NRBP2, PAK3, PAK6, STK32C, STK36, WNK3 |
| Light Kinase (34) | ABL1, AXL, CKB, DGKA, DGKB, DMPK, EIF2AK4, EPHA1, EPHA5, ERBB2, FGR, IGF1R, IKBKB, IKBKE, LIMK2, LRRK2, MAP2K5, MAP3K11, MAP3K12, MAPK3, MYLK, NPR1, PIK3CB, PKDCC, PRKCD, PRKD1, PRKY, RAF1, ROS1, STK16, STRADA, TIE1, TRIO, ULK2 |
| Non-kinase Count | 1605 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_FOCAL_ADHESION | 0.0e+00 | 0.0e+00 | 1652 | 199 | 37 | ACTN1,ACTN4,BAD,BCAR1,CAV3,CCND3,COL1A1,COL1A2,COL3A1,COL5A2,DOCK1,ERBB2,IGF1R,ITGA11,ITGB4,ITGB8,LAMA3,LAMB1,LAMB2,MAPK3,MYL9,MYLK,PAK3,PAK6,PARVB,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PPP1CB,RAC3,RAF1,TLN1,VEGFB,VWF |
| KEGG_REGULATION_OF_ACTIN_CYTOSKELETON | 0.0e+00 | 0.0e+00 | 1652 | 213 | 30 | ACTN1,ACTN4,ARPC5,BCAR1,CFL1,DOCK1,F2R,FGD3,FGF7,ITGA11,ITGB4,ITGB8,LIMK2,MAPK3,MRAS,MYL9,MYLK,PAK3,PAK6,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIP4K2B,PPP1CB,RAC3,RAF1,SSH3 |
| KEGG_PATHWAYS_IN_CANCER | 0.0e+00 | 0.0e+00 | 1652 | 325 | 36 | ABL1,AR,AXIN2,BAD,BMP4,CDKN2B,CTNNA3,ERBB2,FGF7,FZD6,IGF1R,IKBKB,LAMA3,LAMB1,LAMB2,MAPK3,MECOM,MITF,MMP2,PIAS3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PLD1,PPARD,RAC3,RAF1,RXRA,SMAD3,STAT3,STK36,TP53,VEGFB,WNT5A,ZBTB16 |
| KEGG_AXON_GUIDANCE | 0.0e+00 | 1.0e-07 | 1652 | 129 | 21 | ABL1,CFL1,CXCL12,EFNA5,EPHA1,EPHA5,GNAI1,LIMK2,MAPK3,NTN4,PAK3,PAK6,PLXNB1,PLXNB2,PLXNB3,PLXNC1,RAC3,SEMA3B,SEMA3C,SEMA3E,SEMA4A |
| KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM | 0.0e+00 | 1.0e-07 | 1652 | 76 | 16 | CALM3,DGKA,DGKB,IMPA2,INPP5A,INPP5D,INPP5J,INPPL1,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIP4K2B,PLCB1,PLCD4,PLCE1 |
| KEGG_PANCREATIC_CANCER | 0.0e+00 | 2.0e-07 | 1652 | 70 | 15 | BAD,ERBB2,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PLD1,RAC3,RAF1,SMAD3,STAT3,TP53,VEGFB |
| KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 0.0e+00 | 4.0e-07 | 1652 | 96 | 17 | ARPC5,CFL1,DNM1,FCGR2A,INPP5D,LIMK2,MAPK3,MARCKSL1,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIP4K2B,PLD1,PRKCD,PTPRC,RAF1 |
| KEGG_DRUG_METABOLISM_CYTOCHROME_P450 | 1.0e-07 | 2.0e-06 | 1652 | 72 | 14 | ALDH3A1,ALDH3B1,CYP2C18,CYP2E1,FMO1,FMO2,FMO3,GSTA1,GSTA2,GSTM2,MAOA,MGST2,UGT1A6,UGT2B11 |
| KEGG_ECM_RECEPTOR_INTERACTION | 1.0e-07 | 2.1e-06 | 1652 | 84 | 15 | CD36,COL1A1,COL1A2,COL3A1,COL5A2,DAG1,HSPG2,ITGA11,ITGB4,ITGB8,LAMA3,LAMB1,LAMB2,SV2A,VWF |
| KEGG_PROSTATE_CANCER | 2.0e-07 | 4.1e-06 | 1652 | 89 | 15 | AR,BAD,CREB3L1,ERBB2,IGF1R,IKBKB,MAPK3,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,TP53 |
| KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION | 2.0e-07 | 4.2e-06 | 1652 | 115 | 17 | ACTA2,ACTG2,ADCY6,CALM3,EDNRA,GNAQ,KCNMB3,MAPK3,MRVI1,MYL9,MYLK,NPR1,PLCB1,PPP1CB,PRKCD,RAF1,RAMP1 |
| KEGG_PPAR_SIGNALING_PATHWAY | 4.0e-07 | 5.7e-06 | 1652 | 69 | 13 | ACADL,APOC3,AQP7,CD36,CPT2,DBI,OLR1,PLIN1,PPARD,RXRA,SCP2,SLC27A2,SLC27A4 |
| KEGG_MELANOMA | 5.0e-07 | 7.4e-06 | 1652 | 71 | 13 | BAD,FGF7,IGF1R,MAPK3,MITF,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,TP53 |
| KEGG_ENDOMETRIAL_CANCER | 9.0e-07 | 1.1e-05 | 1652 | 52 | 11 | AXIN2,BAD,CTNNA3,ERBB2,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,TP53 |
| KEGG_PHENYLALANINE_METABOLISM | 1.0e-06 | 1.2e-05 | 1652 | 18 | 7 | ALDH3A1,ALDH3B1,AOC2,AOC3,HPD,MAOA,NAA80 |
| KEGG_ACUTE_MYELOID_LEUKEMIA | 2.3e-06 | 2.6e-05 | 1652 | 57 | 11 | BAD,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PPARD,RAF1,STAT3,ZBTB16 |
| KEGG_CHRONIC_MYELOID_LEUKEMIA | 4.6e-06 | 5.1e-05 | 1652 | 73 | 12 | ABL1,BAD,IKBKB,MAPK3,MECOM,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,SMAD3,TP53 |
| KEGG_COLORECTAL_CANCER | 5.4e-06 | 5.5e-05 | 1652 | 62 | 11 | AXIN2,BAD,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAC3,RAF1,SMAD3,TP53 |
| KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION | 7.6e-06 | 7.5e-05 | 1652 | 42 | 9 | ATP1A2,ATP1A4,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,SCNN1B,SLC9A3R2 |
| KEGG_GAP_JUNCTION | 8.2e-06 | 7.7e-05 | 1652 | 90 | 13 | ADCY6,GNAI1,GNAQ,GRM1,HTR2C,MAP2K5,MAPK3,PDGFC,PDGFD,PLCB1,RAF1,TUBA3D,TUBA3E |
| KEGG_PEROXISOME | 9.4e-06 | 7.8e-05 | 1652 | 78 | 12 | ABCD1,DDO,DECR2,ECI2,NUDT12,PEX11A,PEX11B,PEX11G,PEX13,PXMP2,SCP2,SLC27A2 |
| KEGG_INOSITOL_PHOSPHATE_METABOLISM | 9.6e-06 | 7.8e-05 | 1652 | 54 | 10 | IMPA2,INPP5A,INPP5J,INPPL1,ISYNA1,PIK3CB,PIP4K2B,PLCB1,PLCD4,PLCE1 |
| KEGG_NON_SMALL_CELL_LUNG_CANCER | 9.6e-06 | 7.8e-05 | 1652 | 54 | 10 | BAD,ERBB2,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,RXRA,TP53 |
| KEGG_RENIN_ANGIOTENSIN_SYSTEM | 1.2e-05 | 9.0e-05 | 1652 | 17 | 6 | ACE2,AGT,ANPEP,CPA3,LNPEP,MME |
| KEGG_CHEMOKINE_SIGNALING_PATHWAY | 1.8e-05 | 1.4e-04 | 1652 | 189 | 19 | ADCY6,BCAR1,CCL28,CCR7,CXCL12,CXCR5,FGR,GNAI1,GNG10,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PLCB1,PRKCD,RAF1,STAT3 |
| KEGG_SMALL_CELL_LUNG_CANCER | 2.0e-05 | 1.5e-04 | 1652 | 84 | 12 | CDKN2B,IKBKB,LAMA3,LAMB1,LAMB2,PIAS3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RXRA,TP53 |
| KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION | 2.3e-05 | 1.6e-04 | 1652 | 85 | 12 | ADCY6,ANAPC11,ANAPC13,GNAI1,IGF1R,MAPK3,PDE3A,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1 |
| gene_type | info |
|---|---|
| Dark Kinase (12) | BRSK1, CDK11B, CDK16, CSNK1G3, MAP3K21, MARK3, PHKG1, RIOK1, RIOK2, RPS6KL1, STK40, VRK2 |
| Light Kinase (35) | AURKA, CASK, CDK4, CDK8, CSNK1A1, CSNK2A1, DGKG, EIF2AK2, EPHA2, FLT1, GAK, HK2, HUNK, IRAK2, MAP2K1, MAP3K4, MAPK9, MAPKAPK3, MAPKAPK5, MARK2, PAK4, PDPK2P, PIM1, PIM2, PLK2, PLK3, PRKAA1, RPS6KB1, SGK3, TAF1, TBK1, TEX14, TRIB2, TRIB3, TRIM33 |
| Non-kinase Count | 1556 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_RIBOSOME | 0.0e+00 | 0.0e+00 | 1603 | 88 | 73 | FAU,RPL10,RPL10A,RPL11,RPL12,RPL13,RPL13A,RPL14,RPL15,RPL17,RPL18,RPL18A,RPL19,RPL22L1,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL27A,RPL28,RPL29,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35,RPL35A,RPL36,RPL36A,RPL37,RPL37A,RPL38,RPL39,RPL4,RPL5,RPL6,RPL7,RPL8,RPL9,RPLP0,RPLP1,RPLP2,RPS10,RPS11,RPS12,RPS13,RPS15,RPS15A,RPS16,RPS18,RPS19,RPS2,RPS20,RPS21,RPS23,RPS24,RPS25,RPS27,RPS27A,RPS28,RPS29,RPS3,RPS3A,RPS4X,RPS5,RPS6,RPS8,RPS9,RPSA,RSL24D1,UBA52 |
| KEGG_AMINOACYL_TRNA_BIOSYNTHESIS | 0.0e+00 | 0.0e+00 | 1603 | 41 | 16 | AARS1,CARS1,DARS1,EARS2,EPRS1,FARSB,GARS1,HARS1,IARS1,KARS1,LARS1,MARS1,PSTK,SARS1,TARS1,YARS1 |
| KEGG_PROTEASOME | 0.0e+00 | 0.0e+00 | 1603 | 46 | 14 | PSMA4,PSMA5,PSMA6,PSMB1,PSMB3,PSMC5,PSMD11,PSMD13,PSMD14,PSMD3,PSMD4,PSMD7,PSME4,PSMF1 |
| KEGG_SPLICEOSOME | 0.0e+00 | 0.0e+00 | 1603 | 127 | 21 | BUD31,CCDC12,CTNNBL1,CWC15,LSM5,MAGOH,PLRG1,PPIE,PRPF3,SF3A1,SF3B6,SMNDC1,SNRNP27,SNRPB2,SNU13,SRSF1,SRSF3,SRSF7,U2AF1,U2AF2,USP39 |
| KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM | 1.0e-06 | 3.8e-05 | 1603 | 44 | 10 | GFPT1,GFPT2,GMPPA,GNPDA1,GNPDA2,HK2,NANS,PGM3,PMM2,UAP1 |
| KEGG_PYRIMIDINE_METABOLISM | 1.5e-05 | 4.8e-04 | 1603 | 98 | 13 | CANT1,NME1-NME2,NME2,NT5C,PNP,POLD2,POLE4,POLR1E,POLR2C,POLR2H,POLR2J,POLR3D,PRIM2 |
| gene_type | info |
|---|---|
| Dark Kinase (11) | CAMKK1, MAST2, NEK1, NEK4, PAN3, PHKG2, PIP5K1A, TAOK1, TESK1, TLK1, ULK4 |
| Light Kinase (20) | ADPGK, BAZ1A, BAZ1B, CAMK2A, CDK3, CSK, DDR2, DGKE, GRK2, HSPB8, MAP3K6, MAPK7, MLKL, PASK, PI4KB, PIK3C3, SLK, STK4, TPTEP2-CSNK1E, TTN |
| Non-kinase Count | 868 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| gene_type | info |
|---|---|
| Dark Kinase (9) | ADCK1, ADCK5, CDC42BPG, COQ8B, MAST3, NEK9, PRAG1, STK32A, TAOK2 |
| Light Kinase (28) | BCR, BRD3, CKMT1A, CKMT1B, EIF2AK1, EPHA7, EPHB6, ERBB4, KDR, LIMK1, MAP3K13, MAP3K5, MAP4K2, MINK1, PRKACA, PRKCA, PRKCH, PRKX, PTK2B, ROCK2, RPS6KA2, SGK1, STK11, STK38, TGFBR2, TNK2, TRIM66, UHMK1 |
| Non-kinase Count | 1088 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_PEROXISOME | 0.0e+00 | 4.0e-07 | 1125 | 78 | 14 | ABCD2,ABCD3,AMACR,CRAT,CROT,FAR2,GSTK1,IDH2,MLYCD,PEX1,PEX2,PEX7,PMVK,PXMP4 |
| KEGG_ENDOCYTOSIS | 0.0e+00 | 2.1e-06 | 1125 | 181 | 19 | ACAP3,ADRB1,ADRB2,AP2A2,ARRB1,ARRB2,ASAP3,DNAJC6,DNM3,ERBB4,HSPA2,IQSEC1,KDR,LDLRAP1,PARD6A,PSD3,RAB11FIP1,RAB4A,SH3GLB2 |
| KEGG_PATHWAYS_IN_CANCER | 0.0e+00 | 2.1e-06 | 1125 | 325 | 26 | APPL1,BCR,CASP9,COL4A1,COL4A2,FGF12,FGF5,FN1,FOXO1,FZD1,FZD3,FZD4,GLI2,GLI3,HIF1A,ITGA3,JUP,LAMA1,LAMA5,PRKCA,PTCH1,RASSF5,RUNX1T1,STAT1,TGFBR2,WNT11 |
| KEGG_WNT_SIGNALING_PATHWAY | 3.0e-07 | 1.5e-05 | 1125 | 150 | 16 | CTNNBIP1,CXXC4,FZD1,FZD3,FZD4,LRP5,PLCB2,PPP2R5A,PRICKLE1,PRICKLE2,PRKACA,PRKCA,PRKX,ROCK2,VANGL1,WNT11 |
| KEGG_AXON_GUIDANCE | 1.4e-06 | 5.2e-05 | 1125 | 129 | 14 | ABLIM1,ABLIM2,EFNB2,EPHA7,EPHB6,LIMK1,ROBO2,ROCK2,SEMA3F,SEMA4F,SEMA4G,SEMA5A,SEMA6D,SRGAP1 |
| KEGG_VIBRIO_CHOLERAE_INFECTION | 3.1e-06 | 9.5e-05 | 1125 | 54 | 9 | ADCY9,ATP6V0A1,ATP6V0E2,ATP6V1E2,ATP6V1G2,MUC2,PRKACA,PRKCA,PRKX |
| KEGG_SULFUR_METABOLISM | 6.3e-06 | 1.7e-04 | 1125 | 13 | 5 | BPNT1,CHST12,PAPSS1,SULT1A4,SUOX |
| gene_type | info |
|---|---|
| Dark Kinase (8) | ADCK2, CAMKK2, CDK13, CSNK1G2, MAST4, NEK6, SCYL3, TP53RK |
| Light Kinase (16) | ALPK1, CLK2, EGFR, MTOR, NLK, PDGFRA, PDK4, PIK3CG, PKN1, PKN2, ROR1, RYK, STK24, STK39, TBRG4, TEK |
| Non-kinase Count | 876 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_OXIDATIVE_PHOSPHORYLATION | 0.0e+00 | 3.1e-06 | 900 | 131 | 15 | ATP5F1A,ATP5MC1,ATP5MC2,ATP5ME,ATP5PO,COX17,COX8A,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,PPA1,PPA2,UQCRFS1 |
| KEGG_HUNTINGTONS_DISEASE | 2.0e-07 | 1.8e-05 | 900 | 180 | 16 | ATP5F1A,ATP5MC1,ATP5MC2,ATP5PO,BDNF,COX8A,CREB3L4,IFT57,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,POLR2G,POLR2I,UQCRFS1 |
| KEGG_SELENOAMINO_ACID_METABOLISM | 3.0e-07 | 1.8e-05 | 900 | 26 | 7 | AHCY,CBS,GGT5,LCMT2,METTL6,SCLY,SEPHS2 |
| KEGG_PARKINSONS_DISEASE | 3.8e-06 | 1.8e-04 | 900 | 128 | 12 | ATP5F1A,ATP5MC1,ATP5MC2,ATP5PO,COX8A,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,PARK7,UQCRFS1 |
| gene_type | info |
|---|---|
| Dark Kinase (7) | BRSK2, CDK18, CDKL2, LTK, MAP3K14, STK31, STK33 |
| Light Kinase (15) | ACVR1B, AKT3, DAPK3, EPHA4, FES, FYN, GRK5, LCK, MAP3K9, MAP4K5, MERTK, NPR2, PRKG1, TNK1, TNNI3K |
| Non-kinase Count | 714 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 8e-07 | 0.00014 | 736 | 272 | 17 | ADRA1B,C5AR1,GABBR2,GABRR2,GIPR,GRIA2,GRIK2,GRIN2A,OPRM1,P2RY2,P2RY4,PLG,PRLHR,PTGIR,PTH2R,TBXA2R,THRB |
| gene_type | info |
|---|---|
| Dark Kinase (6) | CDK20, CLK4, DYRK3, DYRK4, NEK3, NUAK2 |
| Light Kinase (12) | ACVR2B, AURKC, BMPR1B, BRAF, CDK7, CSNK1E, MAP3K20, PIM3, PTK6, RIPK2, TRIB1, TRPM6 |
| Non-kinase Count | 536 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_PATHWAYS_IN_CANCER | 0.0e+00 | 0.0e+00 | 554 | 325 | 22 | BIRC2,BMP2,BRAF,CDKN1B,CSF3R,DVL1,ETS1,FGF2,IKBKG,IL6,ITGA2B,LAMB3,LAMC2,MMP1,NFKB2,NFKBIA,PPARG,PTGS2,SMAD2,STAT5A,TRAF1,VEGFA |
| KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY | 0.0e+00 | 2.0e-07 | 554 | 62 | 10 | BIRC2,CXCL1,IKBKG,IL1B,IL6,NFKBIA,NLRC4,NLRP3,RIPK2,TNFAIP3 |
| KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 0.0e+00 | 6.0e-07 | 554 | 265 | 17 | ACVR2B,BMP2,BMPR1B,CSF2,CSF3,CSF3R,CXCL1,CXCL10,IL1A,IL1B,IL6,INHBA,LTBR,PRLR,TNFRSF12A,TSLP,VEGFA |
| KEGG_CIRCADIAN_RHYTHM_MAMMAL | 2.0e-07 | 9.1e-06 | 554 | 13 | 5 | BHLHE40,BHLHE41,CSNK1E,NPAS2,PER1 |
| KEGG_SMALL_CELL_LUNG_CANCER | 4.0e-07 | 1.5e-05 | 554 | 84 | 9 | BIRC2,CDKN1B,IKBKG,ITGA2B,LAMB3,LAMC2,NFKBIA,PTGS2,TRAF1 |
| KEGG_MAPK_SIGNALING_PATHWAY | 1.1e-05 | 3.3e-04 | 554 | 267 | 13 | BRAF,DUSP10,DUSP16,DUSP8,FGF2,GADD45B,IKBKG,IL1A,IL1B,MAP3K20,NFKB2,NGF,RELB |
| KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY | 1.4e-05 | 3.8e-04 | 554 | 71 | 7 | CXCL10,DDX58,DHX58,IFIH1,IKBKG,ISG15,NFKBIA |
| gene_type | info |
|---|---|
| Dark Kinase (5) | CDC42BPA, CDK10, POMK, PSKH1, TSSK6 |
| Light Kinase (16) | CAMK1, CDK6, CHEK2, DCLK2, FASTK, LATS1, MAPK12, MAPK14, MOK, PIK3R4, PRKG2, RPS6KA4, RPS6KB2, STK25, TYK2, WNK4 |
| Non-kinase Count | 575 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_OXIDATIVE_PHOSPHORYLATION | 0 | 0e+00 | 596 | 131 | 15 | ATP5MC3,ATP5MF,COX15,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,SDHA,UQCR10 |
| KEGG_ALZHEIMERS_DISEASE | 0 | 0e+00 | 596 | 165 | 16 | ATP5MC3,CASP8,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,PPP3CA,SDHA,TNFRSF1A,UQCR10 |
| KEGG_HUNTINGTONS_DISEASE | 0 | 0e+00 | 596 | 180 | 16 | ATP5MC3,BAX,CASP8,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,SDHA,SP1,UQCR10 |
| KEGG_PARKINSONS_DISEASE | 0 | 2e-07 | 596 | 128 | 13 | ATP5MC3,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,SDHA,UQCR10 |
| gene_type | info |
|---|---|
| Dark Kinase (4) | EEF2K, PKMYT1, PRPF4B, RSKR |
| Light Kinase (23) | AKT1, ATR, BUB1B, CDC7, CHUK, CIT, EPHA3, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GRK6, HASPIN, MAP3K7, PBK, PI4K2B, PLK1, PRKDC, RPS6KA1, STRADB, TRIM28, TTK, VRK1 |
| Non-kinase Count | 1112 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_PYRIMIDINE_METABOLISM | 0 | 0e+00 | 1139 | 98 | 29 | CAD,DHODH,DTYMK,DUT,ENTPD6,NME1,PNPT1,POLA1,POLA2,POLD1,POLE2,POLE3,POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K,PRIM1,RRM2,TK1,TYMS,UMPS |
| KEGG_DNA_REPLICATION | 0 | 0e+00 | 1139 | 36 | 20 | DNA2,FEN1,LIG1,MCM2,MCM5,MCM6,POLA1,POLA2,POLD1,POLE2,POLE3,PRIM1,RFC2,RFC3,RFC4,RFC5,RNASEH1,RPA1,RPA3,SSBP1 |
| KEGG_PURINE_METABOLISM | 0 | 0e+00 | 1139 | 159 | 34 | ADCY3,ENTPD2,ENTPD6,GART,HPRT1,IMPDH1,NME1,NUDT5,PAICS,PDE4A,PDE7A,PNPT1,POLA1,POLA2,POLD1,POLE2,POLE3,POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K,PPAT,PRIM1,PRPS1,PRPS2,RRM2 |
| KEGG_CELL_CYCLE | 0 | 0e+00 | 1139 | 124 | 29 | ANAPC1,ANAPC10,ANAPC4,ATR,BUB1B,BUB3,CCNE1,CDC20,CDC45,CDC7,DBF4,E2F4,HDAC2,MAD2L1,MCM2,MCM5,MCM6,ORC1,ORC2,ORC5,PKMYT1,PLK1,PRKDC,PTTG1,SKP2,SMC1A,TFDP1,TGFB2,TTK |
| KEGG_SPLICEOSOME | 0 | 0e+00 | 1139 | 127 | 28 | AQR,CDC5L,DHX15,EFTUD2,HNRNPC,LSM3,LSM6,LSM7,NCBP1,PPIH,PPIL1,PRPF19,PRPF38B,PRPF4,PRPF40A,SF3B4,SNRNP200,SNRNP40,SNRNP70,SNRPC,SNRPD1,SNRPD3,SNRPF,SNRPG,SRSF10,SRSF9,THOC3,TXNL4A |
| KEGG_MISMATCH_REPAIR | 0 | 0e+00 | 1139 | 23 | 13 | EXO1,LIG1,MLH1,MLH3,MSH6,POLD1,RFC2,RFC3,RFC4,RFC5,RPA1,RPA3,SSBP1 |
| KEGG_HOMOLOGOUS_RECOMBINATION | 0 | 0e+00 | 1139 | 28 | 12 | BLM,EME1,MRE11,POLD1,RAD51C,RAD54B,RPA1,RPA3,SSBP1,TOP3B,XRCC2,XRCC3 |
| KEGG_RNA_POLYMERASE | 0 | 0e+00 | 1139 | 29 | 12 | POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K |
| KEGG_BASE_EXCISION_REPAIR | 0 | 0e+00 | 1139 | 35 | 12 | APEX1,APEX2,FEN1,HMGB1,LIG1,NEIL2,NTHL1,PARP1,POLD1,POLE2,POLE3,TDG |
| KEGG_NUCLEOTIDE_EXCISION_REPAIR | 0 | 1e-07 | 1139 | 44 | 11 | GTF2H3,LIG1,POLD1,POLE2,POLE3,RFC2,RFC3,RFC4,RFC5,RPA1,RPA3 |
| KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS | 0 | 2e-07 | 1139 | 134 | 17 | ANAPC1,ANAPC10,ANAPC4,BRCA1,CDC20,CUL2,FANCL,PRPF19,SAE1,SKP2,UBE2G2,UBE2L3,UBE2N,UBE2NL,UBE2S,UBE3C,VHL |
| KEGG_OOCYTE_MEIOSIS | 0 | 6e-07 | 1139 | 112 | 15 | ADCY3,ANAPC1,ANAPC10,ANAPC4,CCNE1,CDC20,FBXO5,MAD2L1,PKMYT1,PLK1,PPP1CC,PTTG1,RPS6KA1,SGO1,SMC1A |
| gene_type | info |
|---|---|
| Dark Kinase (4) | OBSCN, STK17A, STK17B, TSSK4 |
| Light Kinase (14) | BLVRA, GRK3, GRK4, MAP3K1, MAPK13, MET, MYO3B, NTRK3, PDK3, PIK3CD, PRKCI, SNRK, SYK, TNIK |
| Non-kinase Count | 379 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_ENDOCYTOSIS | 0 | 0 | 397 | 181 | 14 | ACAP1,ARFGAP1,CBLB,CHMP2B,CHMP4C,EHD4,GRK3,GRK4,HLA-B,LDLR,MET,PRKCI,SH3GL3,VPS37B |
| gene_type | info |
|---|---|
| Dark Kinase (2) | MKNK2, NIM1K |
| Light Kinase (5) | DYRK1A, MAP3K2, PDK1, PRKAA2, TEC |
| Non-kinase Count | 390 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_GLYCOLYSIS_GLUCONEOGENESIS | 0.0e+00 | 3.0e-07 | 397 | 62 | 9 | ALDOA,ENO1,ENO2,GAPDH,GPI,LDHA,PGK1,PKM,TPI1 |
| KEGG_PENTOSE_PHOSPHATE_PATHWAY | 2.2e-06 | 2.0e-04 | 397 | 27 | 5 | ALDOA,GPI,PGD,TALDO1,TKT |
| KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM | 7.1e-06 | 4.4e-04 | 397 | 34 | 5 | AKR1B1,AKR1B10,ALDOA,PFKFB4,TPI1 |
| gene_type | info |
|---|---|
| Dark Kinase (2) | BCKDK, TBCK |
| Light Kinase (1) | DDR1 |
| Non-kinase Count | 118 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| gene_type | info |
|---|---|
| Dark Kinase (2) | PI4KA, RNASEL |
| Light Kinase (16) | BMPR2, CDK5, EPHA10, EPHB4, FPGT-TNNI3K, JAK3, MAP2K4, PDGFRB, PDK2, PIK3C2A, PRKD3, PTK7, ROCK1, SPEG, SRC, TRIM24 |
| Non-kinase Count | 435 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| gene_type | info |
|---|---|
| Dark Kinase (2) | PKN3, TSSK3 |
| Light Kinase (14) | AKT2, BMPR1A, DGKH, DGKI, HIPK2, IRAK1, MAP3K3, MAP4K3, PDPK1, PIK3CA, RIPK1, SIK2, TRRAP, WNK1 |
| Non-kinase Count | 276 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_ENDOMETRIAL_CANCER | 0.0e+00 | 2.8e-06 | 292 | 52 | 7 | AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2 |
| KEGG_NON_SMALL_CELL_LUNG_CANCER | 0.0e+00 | 2.8e-06 | 292 | 54 | 7 | AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2 |
| KEGG_PROSTATE_CANCER | 1.0e-07 | 2.9e-06 | 292 | 89 | 8 | AKT2,EP300,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2 |
| KEGG_NEUROTROPHIN_SIGNALING_PATHWAY | 1.0e-07 | 2.9e-06 | 292 | 126 | 9 | AKT2,HRAS,IRAK1,MAP3K3,NRAS,PDPK1,PIK3CA,SOS1,SOS2 |
| KEGG_INSULIN_SIGNALING_PATHWAY | 1.0e-07 | 4.8e-06 | 292 | 137 | 9 | AKT2,HRAS,NRAS,PDPK1,PHKB,PIK3CA,PRKAR1A,SOS1,SOS2 |
| KEGG_RENAL_CELL_CARCINOMA | 2.0e-07 | 5.8e-06 | 292 | 70 | 7 | AKT2,EP300,HRAS,NRAS,PIK3CA,SOS1,SOS2 |
| KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY | 4.0e-07 | 1.2e-05 | 292 | 79 | 7 | AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2 |
| KEGG_ACUTE_MYELOID_LEUKEMIA | 1.1e-06 | 2.5e-05 | 292 | 57 | 6 | AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2 |
| KEGG_GLIOMA | 2.3e-06 | 4.8e-05 | 292 | 65 | 6 | AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2 |
| KEGG_FOCAL_ADHESION | 3.0e-06 | 5.5e-05 | 292 | 199 | 9 | AKT2,HRAS,ITGA10,PARVA,PDPK1,PIK3CA,SOS1,SOS2,ZYX |
| KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 3.6e-06 | 6.1e-05 | 292 | 108 | 7 | AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2 |
| KEGG_CHRONIC_MYELOID_LEUKEMIA | 4.6e-06 | 7.2e-05 | 292 | 73 | 6 | AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2 |
| KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY | 5.4e-06 | 7.7e-05 | 292 | 75 | 6 | AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2 |
| KEGG_ERBB_SIGNALING_PATHWAY | 1.3e-05 | 1.7e-04 | 292 | 87 | 6 | AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2 |
| KEGG_GNRH_SIGNALING_PATHWAY | 3.0e-05 | 3.7e-04 | 292 | 101 | 6 | HRAS,MAP3K3,MMP14,NRAS,SOS1,SOS2 |
| KEGG_JAK_STAT_SIGNALING_PATHWAY | 3.8e-05 | 4.4e-04 | 292 | 155 | 7 | AKT2,EP300,IL13RA1,PIK3CA,SOS1,SOS2,STAT6 |
| KEGG_REGULATION_OF_ACTIN_CYTOSKELETON | 4.0e-05 | 4.4e-04 | 292 | 213 | 8 | ARPC1B,ARPC4,HRAS,ITGA10,NRAS,PIK3CA,SOS1,SOS2 |
| gene_type | info |
|---|---|
| Dark Kinase (2) | CSNK2A3, PRKACB |
| Light Kinase (3) | DGKQ, ERBB3, RPS6KA6 |
| Non-kinase Count | 370 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| KEGG_ALZHEIMERS_DISEASE | 0 | 0e+00 | 375 | 165 | 14 | ATP5F1C,ATP5F1E,ATP5PD,CALM1,COX7A2,COX7C,FADD,NDUFA4L2,NDUFB1,NDUFB5,PPP3CB,UQCR11,UQCRB,UQCRQ |
| KEGG_HUNTINGTONS_DISEASE | 0 | 0e+00 | 375 | 180 | 14 | ATP5F1C,ATP5F1E,ATP5PD,COX7A2,COX7C,CREB3L2,DNAL4,NDUFA4L2,NDUFB1,NDUFB5,POLR2E,UQCR11,UQCRB,UQCRQ |
| KEGG_OXIDATIVE_PHOSPHORYLATION | 0 | 0e+00 | 375 | 131 | 12 | ATP5F1C,ATP5F1E,ATP5PD,ATP6V0D1,COX7A2,COX7C,NDUFA4L2,NDUFB1,NDUFB5,UQCR11,UQCRB,UQCRQ |
| KEGG_PARKINSONS_DISEASE | 0 | 2e-07 | 375 | 128 | 11 | ATP5F1C,ATP5F1E,ATP5PD,COX7A2,COX7C,NDUFA4L2,NDUFB1,NDUFB5,UQCR11,UQCRB,UQCRQ |
| gene_type | info |
|---|---|
| Dark Kinase (2) | ALPK2, PXK |
| Light Kinase (4) | BRDT, ERN1, MAK, PRKCE |
| Non-kinase Count | 248 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|
| gene_type | info |
|---|---|
| Dark Kinase (1) | CDK14 |
| Light Kinase (3) | AATK, OXSR1, RIPK4 |
| Non-kinase Count | 171 |
| label | pval | fdr | signature | geneset | overlap | hits |
|---|---|---|---|---|---|---|