This preliminary report details the results of looking for pathway enrichment in each of the groups of genes produced by hierarchical clustering of the drug perturbations. I’ve cut the the data into 20, but this value can be changed if we decide on a different value. Otherwise, this analysis focuses on enriched pathways in the KEGG database. Specifically, this analysis uses the C2 KEGG segment from: https://www.gsea-msigdb.org/gsea/msigdb.

As for this report, the panel on the left is sorted by the number of dark kinases in the cluster and displays both the number of pathway hits and dark kinases in the cluster. The number of each cluster is arbitrary. The entry for each cluster displays the kinases associated with the cluster along with the number of non-kinases genes. Below this table are the pathways that passed the enrichment analysis at the 0.01 false discovery rate level. I also corrected for running this analysis for all 20 clusters.

Overall Enrichment Stats

Overall, 92 pathways are enriched in at least one of the following clusters. Of these pathways 60 are only hit once. The following pathways are seen in two or more clusters:

Num: 12 (Pathways: 17 DK: 19)

gene_type info
Dark Kinase (19) CAMK1D, CAMKV, CDKL3, DYRK1B, LMTK2, LMTK3, MAP3K15, MAPK15, MARK1, MKNK1, NEK5, PIK3C2B, PIP5K1B, SBK1, SCYL2, STK3, TESK2, TSSK1B, VRK3
Light Kinase (46) ACVR1C, ACVR2A, ACVRL1, ANKK1, BMP2K, BMX, CAMK2B, CAMK4, CDK9, CSF1R, DAPK1, DAPK2, DCLK1, EPHA6, EPHB2, EPHB3, FGFR1, FGFR2, FGFR3, FGFR4, FLT4, HCK, ITK, JAK2, KALRN, KSR1, KSR2, MAP2K3, MAP2K6, MAP4K1, MAPK10, MAPK11, MAST1, MATK, PI4KAP2, PRKCG, PRKCZ, PRKD2, PTK2, RPS6KA3, SGK2, SRPK2, STK26, STYK1, TAF1L, TXK
Non-kinase Count 1748
label pval fdr signature geneset overlap hits
KEGG_CELL_ADHESION_MOLECULES_CAMS 0.0e+00 0.0e+00 1813 133 32 CD22,CD34,CD40,CD6,CD86,CDH1,CDH15,CDH2,CDH3,CLDN10,CLDN23,CNTN1,ESAM,HLA-DPB1,ICAM2,ITGA6,ITGAL,ITGAM,ITGB7,JAM3,NCAM1,NECTIN2,NEO1,NFASC,NRXN1,NRXN2,NRXN3,OCLN,SELL,SELPLG,SPN,VCAN
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0.0e+00 0.0e+00 1813 272 42 ADCYAP1R1,ADRA1A,AVPR1A,CHRM4,CHRNA10,CHRNA7,CHRNB2,CHRNB4,DRD2,DRD4,FPR2,GABRA1,GABRA6,GABRB2,GABRD,GABRP,GABRQ,GHR,GLRA3,GRID1,GRIK4,GRIK5,GRIN1,GRM7,HTR2A,LTB4R2,MC2R,NMUR1,NPFFR1,NPFFR2,NPY1R,OPRD1,OPRK1,P2RX7,P2RY1,P2RY8,PTAFR,PTGER4,S1PR3,S1PR5,SSTR2,VIPR2
KEGG_MAPK_SIGNALING_PATHWAY 0.0e+00 0.0e+00 1813 267 35 CACNA1G,CACNA1I,CACNA2D1,CACNA2D2,CACNB2,CACNG7,CHP2,DUSP1,DUSP9,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FGFR4,GRB2,IL1R2,JUN,MAP2K3,MAP2K6,MAP4K1,MAPK10,MAPK11,MAPK8IP1,MAPK8IP2,MKNK1,NFATC4,PLA2G2D,PLA2G4A,PLA2G4E,PRKCG,RASGRF1,RPS6KA3,STK3
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0.0e+00 2.0e-07 1813 213 28 ACTN2,APC2,CFL2,CHRM4,CYFIP2,ENAH,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FGFR4,ITGA6,ITGAL,ITGAM,ITGAX,ITGB7,MYH14,MYL2,NCKAP1L,PIK3R5,PIP4K2A,PIP5K1B,PTK2,SCIN,VAV1,WAS
KEGG_CALCIUM_SIGNALING_PATHWAY 0.0e+00 3.0e-07 1813 177 25 ADCY4,ADRA1A,ATP2A3,ATP2B2,AVPR1A,CACNA1G,CACNA1I,CAMK2B,CAMK4,CD38,CHP2,CHRNA7,GNAL,GRIN1,HTR2A,LTB4R2,NOS1,NOS2,P2RX7,PDE1B,PLCD1,PRKCG,PTAFR,RYR1,RYR3
KEGG_AXON_GUIDANCE 0.0e+00 3.0e-07 1813 129 21 CFL2,CHP2,DCC,DPYSL5,EFNA2,EPHA6,EPHB2,EPHB3,LRRC4C,NCK2,NFATC4,NTN1,PTK2,ROBO1,SEMA4D,SEMA5B,SEMA7A,SLIT1,SLIT3,SRGAP3,UNC5B
KEGG_TIGHT_JUNCTION 3.0e-07 8.6e-06 1813 132 19 ACTN2,CGN,CLDN10,CLDN23,IGSF5,JAM3,MAGI2,MYH14,MYH15,MYL2,OCLN,PARD6G,PPP2R2C,PRKCG,PRKCZ,RAB3B,SPTAN1,SYMPK,TJP1
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 5.0e-07 1.2e-05 1813 265 28 ACVR2A,ACVRL1,CCL26,CCR6,CD40,CD70,CSF1R,CX3CR1,CXCR2,EDA,FLT4,GHR,IFNLR1,IL11,IL12A,IL19,IL1R2,IL23R,IL2RB,IL3RA,IL7,INHBB,INHBC,NGFR,TNFRSF19,TNFRSF8,TNFSF10,TNFSF15
KEGG_O_GLYCAN_BIOSYNTHESIS 8.0e-07 1.6e-05 1813 30 9 B4GALT5,GALNT10,GALNT13,GALNT16,GALNT6,GALNT9,GCNT3,GCNT4,ST3GAL2
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.0e-06 1.9e-05 1813 116 17 ACTN2,CLDN10,CLDN23,CYBB,ESAM,ITGAL,ITGAM,ITK,JAM3,MAPK11,MYL2,OCLN,PIK3R5,PRKCG,PTK2,TXK,VAV1
KEGG_PATHWAYS_IN_CANCER 3.4e-06 5.8e-05 1813 325 30 APC2,CBL,CDH1,CDKN2A,CEBPA,CSF1R,DAPK1,DAPK2,DCC,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FZD9,GLI1,GRB2,ITGA6,JUN,LAMA4,MAPK10,NKX3-1,NOS2,PIK3R5,PRKCG,PTK2,RARB,TCF7,TCF7L1
KEGG_CARDIAC_MUSCLE_CONTRACTION 4.4e-06 6.8e-05 1813 78 13 ATP1A3,ATP1B1,ATP1B2,CACNA2D1,CACNA2D2,CACNB2,CACNG7,COX6B2,COX7B2,MYL2,TNNI3,TNNT2,UQCRHL
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.0e-05 1.5e-04 1813 137 17 CHP2,GRB2,ICAM2,ITGAL,KLRC1,KLRC3,NFATC4,PIK3R5,PRKCG,RAET1G,SH2D1A,SHC4,TNFSF10,ULBP1,ULBP2,ULBP3,VAV1
KEGG_HEMATOPOIETIC_CELL_LINEAGE 1.5e-05 2.0e-04 1813 87 13 CD1D,CD22,CD34,CD38,CD3D,CR2,CSF1R,IL11,IL1R2,IL3RA,IL7,ITGA6,ITGAM
KEGG_LONG_TERM_DEPRESSION 4.2e-05 4.8e-04 1813 70 11 GNAO1,GNAZ,GUCY1A1,GUCY1A2,GUCY1B1,NOS1,PLA2G2D,PLA2G4A,PLA2G4E,PRKCG,RYR1
KEGG_TYPE_II_DIABETES_MELLITUS 4.2e-05 4.8e-04 1813 47 9 ABCC8,CACNA1G,KCNJ11,MAFA,MAPK10,PIK3R5,PRKCZ,SLC2A4,SOCS4
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 4.4e-05 4.8e-04 1813 96 13 CFL2,HCK,MYO10,PIK3R5,PIP5K1B,PLA2G4A,PLA2G4E,PLPP2,PRKCG,SCIN,VAV1,WAS,WASF3

Num: 4 (Pathways: 15 DK: 16)

gene_type info
Dark Kinase (16) CDK11A, CDK12, CDK17, CDKL1, CLK3, COQ8A, CSNK1G1, CSNK2A2, DYRK2, HIPK1, NEK7, PDIK1L, RIOK3, SCYL1, STK19, TLK2
Light Kinase (41) ABL2, ARAF, ATM, AURKB, BRD4, BTK, BUB1, CAMK2G, CDK1, CDK2, CHEK1, CLK1, DGKZ, FER, GRK7, GSK3A, GTF2F1, HKDC1, IRAK3, LYN, MAP2K7, MAP4K4, MAPK6, MAPK8, MASTL, MELK, MYLK2, NEK2, PAK1, PAK2, PLK4, RPS6KA5, SIK1, SIK1B, SMG1, SRPK1, STK10, STK35, TYRO3, WEE1, YES1
Non-kinase Count 1873
label pval fdr signature geneset overlap hits
KEGG_SPLICEOSOME 0.0e+00 0.0e+00 1930 127 39 ALYREF,BCAS2,CDC40,CHERP,HNRNPA1,HNRNPA3,HNRNPK,HNRNPU,HSPA6,HSPA8,ISY1,LSM8,MAGOHB,PHF5A,PQBP1,PRPF18,PRPF38A,PUF60,RBM17,RBM22,RBM25,RBM8A,RBMX,SART1,SF3A2,SF3A3,SF3B2,SLU7,SNRPA,SNRPA1,SNRPB,SNW1,SRSF4,SYF2,TCERG1,THOC1,U2SURP,WBP11,XAB2
KEGG_PROTEASOME 0.0e+00 0.0e+00 1930 46 20 POMP,PSMA1,PSMA2,PSMA3,PSMA7,PSMB2,PSMB5,PSMB6,PSMB7,PSMC1,PSMC2,PSMC3,PSMC4,PSMC6,PSMD1,PSMD12,PSMD2,PSMD6,PSMD8,PSME2
KEGG_RNA_DEGRADATION 0.0e+00 0.0e+00 1930 59 20 C1D,CNOT10,CNOT2,CNOT3,CNOT4,CNOT6,CNOT6L,CNOT9,DCP1A,DCP2,DIS3,EXOSC10,EXOSC3,EXOSC4,EXOSC5,EXOSC9,HSPA9,LSM8,PAPOLA,TENT4A
KEGG_CELL_CYCLE 0.0e+00 0.0e+00 1930 124 27 ATM,BUB1,CCNA2,CCNB1,CCNB2,CDC16,CDC25A,CDC25C,CDC27,CDC6,CDK1,CDK2,CHEK1,CREBBP,CUL1,E2F3,ESPL1,MCM7,ORC6,RAD21,SFN,SMAD4,SMC1B,STAG1,STAG2,TFDP2,WEE1
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0.0e+00 0.0e+00 1930 134 27 CDC16,CDC27,COP1,CUL1,CUL3,CUL4A,DDB1,ERCC8,FBXO2,FBXW11,ITCH,PML,RCHY1,RNF7,SMURF1,TRIP12,UBA2,UBA6,UBE2A,UBE2C,UBE2D3,UBE2I,UBE2K,UBE2M,UBE2Z,UBE3A,XIAP
KEGG_OOCYTE_MEIOSIS 0.0e+00 0.0e+00 1930 112 22 BUB1,CAMK2G,CCNB1,CCNB2,CDC16,CDC25C,CDC27,CDK1,CDK2,CPEB1,CUL1,ESPL1,FBXW11,ITPR3,PPP2CB,PPP2R1B,PPP2R5D,PPP2R5E,PPP3CC,PPP3R1,SMC1B,SPDYA
KEGG_HUNTINGTONS_DISEASE 0.0e+00 2.0e-07 1930 180 26 AP2B1,ATP5F1B,ATP5PB,CASP3,CLTA,CLTB,CLTC,COX5A,CREB1,CREBBP,CYC1,DCTN4,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,NRF1,POLR2J2,SLC25A5,SOD1,TBPL2,UQCRC2,UQCRH,VDAC1,VDAC2
KEGG_APOPTOSIS 2.0e-07 4.7e-06 1930 87 16 ATM,BID,CAPN2,CASP10,CASP3,CASP7,DFFB,EXOG,IRAK3,NFKB1,PPP3CC,PPP3R1,TNFRSF10A,TNFRSF10D,TRAF2,XIAP
KEGG_ALZHEIMERS_DISEASE 1.8e-06 3.6e-05 1930 165 21 APH1A,ATP5F1B,ATP5PB,BID,CAPN2,CASP3,CASP7,COX5A,CYC1,HSD17B10,ITPR3,NAE1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,PPP3CC,PPP3R1,UQCRC2,UQCRH
KEGG_PROTEIN_EXPORT 2.1e-06 3.8e-05 1930 24 8 SEC11A,SEC61A2,SEC62,SEC63,SPCS2,SRP72,SRP9P1,SRPRB
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 4.5e-06 7.6e-05 1930 85 14 ARAF,BUB1,CCNA2,CCNB1,CCNB2,CDC16,CDC25A,CDC25C,CDC27,CDK1,CDK2,CPEB1,MAPK8,SPDYA
KEGG_ENDOCYTOSIS 7.7e-06 1.2e-04 1930 181 21 ACAP2,AP2B1,CHMP4B,CHMP5,CLTA,CLTB,CLTC,DNM2,GRK7,HGS,HSPA6,HSPA8,ITCH,PARD3,RAB11FIP2,RBSN,SH3KBP1,SMURF1,STAM,VPS37A,VPS4A
KEGG_P53_SIGNALING_PATHWAY 1.0e-05 1.5e-04 1930 68 12 ATM,BID,CASP3,CCNB1,CCNB2,CDK1,CDK2,CHEK1,COP1,MDM4,RCHY1,SFN
KEGG_WNT_SIGNALING_PATHWAY 2.1e-05 2.8e-04 1930 150 18 AXIN1,CAMK2G,CREBBP,CSNK2A2,CTBP2,CUL1,DVL3,FBXW11,MAPK8,PPP2CB,PPP2R1B,PPP2R5D,PPP2R5E,PPP3CC,PPP3R1,SMAD4,TCF7L2,WNT9B
KEGG_PARKINSONS_DISEASE 3.6e-05 4.5e-04 1930 128 16 ATP5F1B,ATP5PB,CASP3,COX5A,CYC1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,SLC25A5,UBB,UQCRC2,UQCRH,VDAC1,VDAC2

Num: 11 (Pathways: 17 DK: 14)

gene_type info
Dark Kinase (14) CDK19, DSTYK, HIPK3, LRRK1, MAP3K10, MARK4, NEK11, PIP4K2C, PIP5K1C, RPS6KC1, SBK3, SRPK3, STK38L, TTBK2
Light Kinase (32) AAK1, ABR, ACVR1, BRD2, CAMK2D, CSNK1D, DGKD, EIF2AK3, FRK, GSK3B, HK1, ILK, INSR, JAK1, LATS2, MAP2K2, MAP3K8, MAPK1, MAPKAPK2, MST1R, MYLK3, MYLK4, NRBP1, NUAK1, PEAK1, PI4K2A, PINK1, SIK3, TAOK3, TGFBR1, TRPM7, ULK1
Non-kinase Count 1183
label pval fdr signature geneset overlap hits
KEGG_LYSOSOME 0.0e+00 0.0e+00 1229 121 25 ATP6AP1,CD164,CD63,CLN3,CLTCL1,CTNS,CTSA,CTSB,CTSD,CTSF,DNASE2,GAA,GALNS,GNS,IGF2R,LAMP2,MANBA,MCOLN1,NEU1,PLA2G15,PSAP,SCARB2,SLC17A5,SMPD1,TPP1
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0.0e+00 0.0e+00 1229 213 28 ACTG1,ARHGEF12,ARHGEF6,ARPC3,BAIAP2,CDC42,CRK,CYFIP1,FGF13,IQGAP1,ITGA1,ITGA7,ITGAV,ITGB1,MAP2K2,MAPK1,MSN,MYL12A,MYL12B,MYL5,MYLK3,PIP4K2C,PIP5K1C,RHOA,RRAS,RRAS2,TIAM2,WASL
KEGG_FOCAL_ADHESION 0.0e+00 0.0e+00 1229 199 25 ACTG1,ARHGAP5,CDC42,COL11A2,COL6A1,COL6A2,CRK,CTNNB1,GSK3B,HGF,ILK,ITGA1,ITGA7,ITGAV,ITGB1,LAMC1,MAPK1,MYL12A,MYL12B,MYL5,MYLK3,PIP5K1C,RAPGEF1,RHOA,THBS3
KEGG_STEROID_BIOSYNTHESIS 0.0e+00 0.0e+00 1229 17 9 CYP51A1,DHCR24,EBP,FDFT1,LSS,MSMO1,NSDHL,SC5D,SOAT1
KEGG_PATHWAYS_IN_CANCER 2.0e-07 6.6e-06 1229 325 26 ARNT,ARNT2,CCDC6,CDC42,CRK,CSF2RA,CTNNA1,CTNNB1,FGF13,FZD8,GSK3B,HGF,ITGAV,ITGB1,JAK1,LAMC1,MAP2K2,MAPK1,NCOA4,PAX8,RALGDS,RHOA,STAT5B,TGFBR1,TRAF6,WNT5B
KEGG_ADHERENS_JUNCTION 2.0e-07 6.6e-06 1229 73 12 ACTG1,BAIAP2,CDC42,CTNNA1,CTNNB1,INSR,IQGAP1,MAPK1,RHOA,SORBS1,TGFBR1,WASL
KEGG_ENDOCYTOSIS 6.0e-07 1.7e-05 1229 181 18 ARAP1,ASAP2,CDC42,CHMP1B,CHMP2A,CLTCL1,CXCR4,DAB2,EPS15,GIT2,MVB12B,PIP5K1C,PSD4,RAB11FIP5,RAB31,RAB5B,SH3GLB1,TRAF6
KEGG_AXON_GUIDANCE 7.0e-07 1.7e-05 1229 129 15 ARHGEF12,CDC42,CHP1,CXCR4,EFNA1,EFNB3,GNAI2,GSK3B,ITGB1,MAPK1,NFAT5,PLXNA3,RHOA,SEMA4B,SEMA6C
KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS 9.0e-07 1.9e-05 1229 15 6 ACAT1,ACAT2,FDPS,HMGCR,HMGCS1,IDI1
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.1e-06 2.0e-05 1229 116 14 ACTG1,ARHGAP5,CDC42,CTNNA1,CTNNB1,CXCR4,GNAI2,ITGB1,MSN,MYL12A,MYL12B,MYL5,NCF2,RHOA
KEGG_TIGHT_JUNCTION 5.1e-06 8.6e-05 1229 132 14 ACTG1,CDC42,CTNNA1,CTNNB1,EXOC3,EXOC4,GNAI2,MYL12A,MYL12B,MYL5,PATJ,RHOA,RRAS,RRAS2
KEGG_FATTY_ACID_METABOLISM 7.3e-06 1.1e-04 1229 42 8 ACAT1,ACAT2,ACOX1,ACSL1,ADH5,EHHADH,HADHA,HADHB
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 8.5e-06 1.2e-04 1229 56 9 ACTG1,ARPC3,CDC42,CTNNB1,ITGB1,LY96,RHOA,WASL,YWHAZ
KEGG_ALZHEIMERS_DISEASE 1.6e-05 2.1e-04 1229 165 15 ADAM17,APP,CAPN1,CHP1,COX6A1,COX6C,EIF2AK3,GRIN2D,GSK3B,ITPR2,LRP1,MAPK1,MT-ATP6,MT-ATP8,PSEN1
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 2.8e-05 3.5e-04 1229 115 12 ADCY2,ARHGEF12,CALCRL,CALD1,GNAS,ITPR2,MAP2K2,MAPK1,MYL6,MYL6B,MYLK3,RHOA
KEGG_ECM_RECEPTOR_INTERACTION 4.1e-05 4.8e-04 1229 84 10 COL11A2,COL6A1,COL6A2,ITGA1,ITGA7,ITGAV,ITGB1,LAMC1,SDC2,THBS3
KEGG_TGF_BETA_SIGNALING_PATHWAY 4.6e-05 5.0e-04 1229 85 10 ACVR1,DCN,MAPK1,RHOA,SKP1,SMAD7,SMAD9,TGFBR1,THBS3,ZFYVE16

Num: 5 (Pathways: 27 DK: 13)

gene_type info
Dark Kinase (13) ALPK3, CDC42BPB, CDK15, CDKL5, ICK, NEK10, NEK8, NRBP2, PAK3, PAK6, STK32C, STK36, WNK3
Light Kinase (34) ABL1, AXL, CKB, DGKA, DGKB, DMPK, EIF2AK4, EPHA1, EPHA5, ERBB2, FGR, IGF1R, IKBKB, IKBKE, LIMK2, LRRK2, MAP2K5, MAP3K11, MAP3K12, MAPK3, MYLK, NPR1, PIK3CB, PKDCC, PRKCD, PRKD1, PRKY, RAF1, ROS1, STK16, STRADA, TIE1, TRIO, ULK2
Non-kinase Count 1605
label pval fdr signature geneset overlap hits
KEGG_FOCAL_ADHESION 0.0e+00 0.0e+00 1652 199 37 ACTN1,ACTN4,BAD,BCAR1,CAV3,CCND3,COL1A1,COL1A2,COL3A1,COL5A2,DOCK1,ERBB2,IGF1R,ITGA11,ITGB4,ITGB8,LAMA3,LAMB1,LAMB2,MAPK3,MYL9,MYLK,PAK3,PAK6,PARVB,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PPP1CB,RAC3,RAF1,TLN1,VEGFB,VWF
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0.0e+00 0.0e+00 1652 213 30 ACTN1,ACTN4,ARPC5,BCAR1,CFL1,DOCK1,F2R,FGD3,FGF7,ITGA11,ITGB4,ITGB8,LIMK2,MAPK3,MRAS,MYL9,MYLK,PAK3,PAK6,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIP4K2B,PPP1CB,RAC3,RAF1,SSH3
KEGG_PATHWAYS_IN_CANCER 0.0e+00 0.0e+00 1652 325 36 ABL1,AR,AXIN2,BAD,BMP4,CDKN2B,CTNNA3,ERBB2,FGF7,FZD6,IGF1R,IKBKB,LAMA3,LAMB1,LAMB2,MAPK3,MECOM,MITF,MMP2,PIAS3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PLD1,PPARD,RAC3,RAF1,RXRA,SMAD3,STAT3,STK36,TP53,VEGFB,WNT5A,ZBTB16
KEGG_AXON_GUIDANCE 0.0e+00 1.0e-07 1652 129 21 ABL1,CFL1,CXCL12,EFNA5,EPHA1,EPHA5,GNAI1,LIMK2,MAPK3,NTN4,PAK3,PAK6,PLXNB1,PLXNB2,PLXNB3,PLXNC1,RAC3,SEMA3B,SEMA3C,SEMA3E,SEMA4A
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0.0e+00 1.0e-07 1652 76 16 CALM3,DGKA,DGKB,IMPA2,INPP5A,INPP5D,INPP5J,INPPL1,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIP4K2B,PLCB1,PLCD4,PLCE1
KEGG_PANCREATIC_CANCER 0.0e+00 2.0e-07 1652 70 15 BAD,ERBB2,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PLD1,RAC3,RAF1,SMAD3,STAT3,TP53,VEGFB
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0.0e+00 4.0e-07 1652 96 17 ARPC5,CFL1,DNM1,FCGR2A,INPP5D,LIMK2,MAPK3,MARCKSL1,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PIP4K2B,PLD1,PRKCD,PTPRC,RAF1
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 1.0e-07 2.0e-06 1652 72 14 ALDH3A1,ALDH3B1,CYP2C18,CYP2E1,FMO1,FMO2,FMO3,GSTA1,GSTA2,GSTM2,MAOA,MGST2,UGT1A6,UGT2B11
KEGG_ECM_RECEPTOR_INTERACTION 1.0e-07 2.1e-06 1652 84 15 CD36,COL1A1,COL1A2,COL3A1,COL5A2,DAG1,HSPG2,ITGA11,ITGB4,ITGB8,LAMA3,LAMB1,LAMB2,SV2A,VWF
KEGG_PROSTATE_CANCER 2.0e-07 4.1e-06 1652 89 15 AR,BAD,CREB3L1,ERBB2,IGF1R,IKBKB,MAPK3,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,TP53
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 2.0e-07 4.2e-06 1652 115 17 ACTA2,ACTG2,ADCY6,CALM3,EDNRA,GNAQ,KCNMB3,MAPK3,MRVI1,MYL9,MYLK,NPR1,PLCB1,PPP1CB,PRKCD,RAF1,RAMP1
KEGG_PPAR_SIGNALING_PATHWAY 4.0e-07 5.7e-06 1652 69 13 ACADL,APOC3,AQP7,CD36,CPT2,DBI,OLR1,PLIN1,PPARD,RXRA,SCP2,SLC27A2,SLC27A4
KEGG_MELANOMA 5.0e-07 7.4e-06 1652 71 13 BAD,FGF7,IGF1R,MAPK3,MITF,PDGFC,PDGFD,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,TP53
KEGG_ENDOMETRIAL_CANCER 9.0e-07 1.1e-05 1652 52 11 AXIN2,BAD,CTNNA3,ERBB2,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,TP53
KEGG_PHENYLALANINE_METABOLISM 1.0e-06 1.2e-05 1652 18 7 ALDH3A1,ALDH3B1,AOC2,AOC3,HPD,MAOA,NAA80
KEGG_ACUTE_MYELOID_LEUKEMIA 2.3e-06 2.6e-05 1652 57 11 BAD,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PPARD,RAF1,STAT3,ZBTB16
KEGG_CHRONIC_MYELOID_LEUKEMIA 4.6e-06 5.1e-05 1652 73 12 ABL1,BAD,IKBKB,MAPK3,MECOM,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,SMAD3,TP53
KEGG_COLORECTAL_CANCER 5.4e-06 5.5e-05 1652 62 11 AXIN2,BAD,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAC3,RAF1,SMAD3,TP53
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 7.6e-06 7.5e-05 1652 42 9 ATP1A2,ATP1A4,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,SCNN1B,SLC9A3R2
KEGG_GAP_JUNCTION 8.2e-06 7.7e-05 1652 90 13 ADCY6,GNAI1,GNAQ,GRM1,HTR2C,MAP2K5,MAPK3,PDGFC,PDGFD,PLCB1,RAF1,TUBA3D,TUBA3E
KEGG_PEROXISOME 9.4e-06 7.8e-05 1652 78 12 ABCD1,DDO,DECR2,ECI2,NUDT12,PEX11A,PEX11B,PEX11G,PEX13,PXMP2,SCP2,SLC27A2
KEGG_INOSITOL_PHOSPHATE_METABOLISM 9.6e-06 7.8e-05 1652 54 10 IMPA2,INPP5A,INPP5J,INPPL1,ISYNA1,PIK3CB,PIP4K2B,PLCB1,PLCD4,PLCE1
KEGG_NON_SMALL_CELL_LUNG_CANCER 9.6e-06 7.8e-05 1652 54 10 BAD,ERBB2,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1,RXRA,TP53
KEGG_RENIN_ANGIOTENSIN_SYSTEM 1.2e-05 9.0e-05 1652 17 6 ACE2,AGT,ANPEP,CPA3,LNPEP,MME
KEGG_CHEMOKINE_SIGNALING_PATHWAY 1.8e-05 1.4e-04 1652 189 19 ADCY6,BCAR1,CCL28,CCR7,CXCL12,CXCR5,FGR,GNAI1,GNG10,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,PLCB1,PRKCD,RAF1,STAT3
KEGG_SMALL_CELL_LUNG_CANCER 2.0e-05 1.5e-04 1652 84 12 CDKN2B,IKBKB,LAMA3,LAMB1,LAMB2,PIAS3,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RXRA,TP53
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 2.3e-05 1.6e-04 1652 85 12 ADCY6,ANAPC11,ANAPC13,GNAI1,IGF1R,MAPK3,PDE3A,PIK3CB,PIK3R1,PIK3R2,PIK3R3,RAF1

Num: 2 (Pathways: 6 DK: 12)

gene_type info
Dark Kinase (12) BRSK1, CDK11B, CDK16, CSNK1G3, MAP3K21, MARK3, PHKG1, RIOK1, RIOK2, RPS6KL1, STK40, VRK2
Light Kinase (35) AURKA, CASK, CDK4, CDK8, CSNK1A1, CSNK2A1, DGKG, EIF2AK2, EPHA2, FLT1, GAK, HK2, HUNK, IRAK2, MAP2K1, MAP3K4, MAPK9, MAPKAPK3, MAPKAPK5, MARK2, PAK4, PDPK2P, PIM1, PIM2, PLK2, PLK3, PRKAA1, RPS6KB1, SGK3, TAF1, TBK1, TEX14, TRIB2, TRIB3, TRIM33
Non-kinase Count 1556
label pval fdr signature geneset overlap hits
KEGG_RIBOSOME 0.0e+00 0.0e+00 1603 88 73 FAU,RPL10,RPL10A,RPL11,RPL12,RPL13,RPL13A,RPL14,RPL15,RPL17,RPL18,RPL18A,RPL19,RPL22L1,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL27A,RPL28,RPL29,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35,RPL35A,RPL36,RPL36A,RPL37,RPL37A,RPL38,RPL39,RPL4,RPL5,RPL6,RPL7,RPL8,RPL9,RPLP0,RPLP1,RPLP2,RPS10,RPS11,RPS12,RPS13,RPS15,RPS15A,RPS16,RPS18,RPS19,RPS2,RPS20,RPS21,RPS23,RPS24,RPS25,RPS27,RPS27A,RPS28,RPS29,RPS3,RPS3A,RPS4X,RPS5,RPS6,RPS8,RPS9,RPSA,RSL24D1,UBA52
KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0.0e+00 0.0e+00 1603 41 16 AARS1,CARS1,DARS1,EARS2,EPRS1,FARSB,GARS1,HARS1,IARS1,KARS1,LARS1,MARS1,PSTK,SARS1,TARS1,YARS1
KEGG_PROTEASOME 0.0e+00 0.0e+00 1603 46 14 PSMA4,PSMA5,PSMA6,PSMB1,PSMB3,PSMC5,PSMD11,PSMD13,PSMD14,PSMD3,PSMD4,PSMD7,PSME4,PSMF1
KEGG_SPLICEOSOME 0.0e+00 0.0e+00 1603 127 21 BUD31,CCDC12,CTNNBL1,CWC15,LSM5,MAGOH,PLRG1,PPIE,PRPF3,SF3A1,SF3B6,SMNDC1,SNRNP27,SNRPB2,SNU13,SRSF1,SRSF3,SRSF7,U2AF1,U2AF2,USP39
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 1.0e-06 3.8e-05 1603 44 10 GFPT1,GFPT2,GMPPA,GNPDA1,GNPDA2,HK2,NANS,PGM3,PMM2,UAP1
KEGG_PYRIMIDINE_METABOLISM 1.5e-05 4.8e-04 1603 98 13 CANT1,NME1-NME2,NME2,NT5C,PNP,POLD2,POLE4,POLR1E,POLR2C,POLR2H,POLR2J,POLR3D,PRIM2

Num: 7 (Pathways: 0 DK: 11)

gene_type info
Dark Kinase (11) CAMKK1, MAST2, NEK1, NEK4, PAN3, PHKG2, PIP5K1A, TAOK1, TESK1, TLK1, ULK4
Light Kinase (20) ADPGK, BAZ1A, BAZ1B, CAMK2A, CDK3, CSK, DDR2, DGKE, GRK2, HSPB8, MAP3K6, MAPK7, MLKL, PASK, PI4KB, PIK3C3, SLK, STK4, TPTEP2-CSNK1E, TTN
Non-kinase Count 868
label pval fdr signature geneset overlap hits

Num: 1 (Pathways: 7 DK: 9)

gene_type info
Dark Kinase (9) ADCK1, ADCK5, CDC42BPG, COQ8B, MAST3, NEK9, PRAG1, STK32A, TAOK2
Light Kinase (28) BCR, BRD3, CKMT1A, CKMT1B, EIF2AK1, EPHA7, EPHB6, ERBB4, KDR, LIMK1, MAP3K13, MAP3K5, MAP4K2, MINK1, PRKACA, PRKCA, PRKCH, PRKX, PTK2B, ROCK2, RPS6KA2, SGK1, STK11, STK38, TGFBR2, TNK2, TRIM66, UHMK1
Non-kinase Count 1088
label pval fdr signature geneset overlap hits
KEGG_PEROXISOME 0.0e+00 4.0e-07 1125 78 14 ABCD2,ABCD3,AMACR,CRAT,CROT,FAR2,GSTK1,IDH2,MLYCD,PEX1,PEX2,PEX7,PMVK,PXMP4
KEGG_ENDOCYTOSIS 0.0e+00 2.1e-06 1125 181 19 ACAP3,ADRB1,ADRB2,AP2A2,ARRB1,ARRB2,ASAP3,DNAJC6,DNM3,ERBB4,HSPA2,IQSEC1,KDR,LDLRAP1,PARD6A,PSD3,RAB11FIP1,RAB4A,SH3GLB2
KEGG_PATHWAYS_IN_CANCER 0.0e+00 2.1e-06 1125 325 26 APPL1,BCR,CASP9,COL4A1,COL4A2,FGF12,FGF5,FN1,FOXO1,FZD1,FZD3,FZD4,GLI2,GLI3,HIF1A,ITGA3,JUP,LAMA1,LAMA5,PRKCA,PTCH1,RASSF5,RUNX1T1,STAT1,TGFBR2,WNT11
KEGG_WNT_SIGNALING_PATHWAY 3.0e-07 1.5e-05 1125 150 16 CTNNBIP1,CXXC4,FZD1,FZD3,FZD4,LRP5,PLCB2,PPP2R5A,PRICKLE1,PRICKLE2,PRKACA,PRKCA,PRKX,ROCK2,VANGL1,WNT11
KEGG_AXON_GUIDANCE 1.4e-06 5.2e-05 1125 129 14 ABLIM1,ABLIM2,EFNB2,EPHA7,EPHB6,LIMK1,ROBO2,ROCK2,SEMA3F,SEMA4F,SEMA4G,SEMA5A,SEMA6D,SRGAP1
KEGG_VIBRIO_CHOLERAE_INFECTION 3.1e-06 9.5e-05 1125 54 9 ADCY9,ATP6V0A1,ATP6V0E2,ATP6V1E2,ATP6V1G2,MUC2,PRKACA,PRKCA,PRKX
KEGG_SULFUR_METABOLISM 6.3e-06 1.7e-04 1125 13 5 BPNT1,CHST12,PAPSS1,SULT1A4,SUOX

Num: 3 (Pathways: 4 DK: 8)

gene_type info
Dark Kinase (8) ADCK2, CAMKK2, CDK13, CSNK1G2, MAST4, NEK6, SCYL3, TP53RK
Light Kinase (16) ALPK1, CLK2, EGFR, MTOR, NLK, PDGFRA, PDK4, PIK3CG, PKN1, PKN2, ROR1, RYK, STK24, STK39, TBRG4, TEK
Non-kinase Count 876
label pval fdr signature geneset overlap hits
KEGG_OXIDATIVE_PHOSPHORYLATION 0.0e+00 3.1e-06 900 131 15 ATP5F1A,ATP5MC1,ATP5MC2,ATP5ME,ATP5PO,COX17,COX8A,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,PPA1,PPA2,UQCRFS1
KEGG_HUNTINGTONS_DISEASE 2.0e-07 1.8e-05 900 180 16 ATP5F1A,ATP5MC1,ATP5MC2,ATP5PO,BDNF,COX8A,CREB3L4,IFT57,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,POLR2G,POLR2I,UQCRFS1
KEGG_SELENOAMINO_ACID_METABOLISM 3.0e-07 1.8e-05 900 26 7 AHCY,CBS,GGT5,LCMT2,METTL6,SCLY,SEPHS2
KEGG_PARKINSONS_DISEASE 3.8e-06 1.8e-04 900 128 12 ATP5F1A,ATP5MC1,ATP5MC2,ATP5PO,COX8A,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,PARK7,UQCRFS1

Num: 10 (Pathways: 1 DK: 7)

gene_type info
Dark Kinase (7) BRSK2, CDK18, CDKL2, LTK, MAP3K14, STK31, STK33
Light Kinase (15) ACVR1B, AKT3, DAPK3, EPHA4, FES, FYN, GRK5, LCK, MAP3K9, MAP4K5, MERTK, NPR2, PRKG1, TNK1, TNNI3K
Non-kinase Count 714
label pval fdr signature geneset overlap hits
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 8e-07 0.00014 736 272 17 ADRA1B,C5AR1,GABBR2,GABRR2,GIPR,GRIA2,GRIK2,GRIN2A,OPRM1,P2RY2,P2RY4,PLG,PRLHR,PTGIR,PTH2R,TBXA2R,THRB

Num: 14 (Pathways: 7 DK: 6)

gene_type info
Dark Kinase (6) CDK20, CLK4, DYRK3, DYRK4, NEK3, NUAK2
Light Kinase (12) ACVR2B, AURKC, BMPR1B, BRAF, CDK7, CSNK1E, MAP3K20, PIM3, PTK6, RIPK2, TRIB1, TRPM6
Non-kinase Count 536
label pval fdr signature geneset overlap hits
KEGG_PATHWAYS_IN_CANCER 0.0e+00 0.0e+00 554 325 22 BIRC2,BMP2,BRAF,CDKN1B,CSF3R,DVL1,ETS1,FGF2,IKBKG,IL6,ITGA2B,LAMB3,LAMC2,MMP1,NFKB2,NFKBIA,PPARG,PTGS2,SMAD2,STAT5A,TRAF1,VEGFA
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.0e+00 2.0e-07 554 62 10 BIRC2,CXCL1,IKBKG,IL1B,IL6,NFKBIA,NLRC4,NLRP3,RIPK2,TNFAIP3
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0.0e+00 6.0e-07 554 265 17 ACVR2B,BMP2,BMPR1B,CSF2,CSF3,CSF3R,CXCL1,CXCL10,IL1A,IL1B,IL6,INHBA,LTBR,PRLR,TNFRSF12A,TSLP,VEGFA
KEGG_CIRCADIAN_RHYTHM_MAMMAL 2.0e-07 9.1e-06 554 13 5 BHLHE40,BHLHE41,CSNK1E,NPAS2,PER1
KEGG_SMALL_CELL_LUNG_CANCER 4.0e-07 1.5e-05 554 84 9 BIRC2,CDKN1B,IKBKG,ITGA2B,LAMB3,LAMC2,NFKBIA,PTGS2,TRAF1
KEGG_MAPK_SIGNALING_PATHWAY 1.1e-05 3.3e-04 554 267 13 BRAF,DUSP10,DUSP16,DUSP8,FGF2,GADD45B,IKBKG,IL1A,IL1B,MAP3K20,NFKB2,NGF,RELB
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 1.4e-05 3.8e-04 554 71 7 CXCL10,DDX58,DHX58,IFIH1,IKBKG,ISG15,NFKBIA

Num: 18 (Pathways: 4 DK: 5)

gene_type info
Dark Kinase (5) CDC42BPA, CDK10, POMK, PSKH1, TSSK6
Light Kinase (16) CAMK1, CDK6, CHEK2, DCLK2, FASTK, LATS1, MAPK12, MAPK14, MOK, PIK3R4, PRKG2, RPS6KA4, RPS6KB2, STK25, TYK2, WNK4
Non-kinase Count 575
label pval fdr signature geneset overlap hits
KEGG_OXIDATIVE_PHOSPHORYLATION 0 0e+00 596 131 15 ATP5MC3,ATP5MF,COX15,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,SDHA,UQCR10
KEGG_ALZHEIMERS_DISEASE 0 0e+00 596 165 16 ATP5MC3,CASP8,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,PPP3CA,SDHA,TNFRSF1A,UQCR10
KEGG_HUNTINGTONS_DISEASE 0 0e+00 596 180 16 ATP5MC3,BAX,CASP8,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,SDHA,SP1,UQCR10
KEGG_PARKINSONS_DISEASE 0 2e-07 596 128 13 ATP5MC3,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB2,NDUFB7,NDUFC1,NDUFS2,NDUFS5,NDUFS6,SDHA,UQCR10

Num: 9 (Pathways: 12 DK: 4)

gene_type info
Dark Kinase (4) EEF2K, PKMYT1, PRPF4B, RSKR
Light Kinase (23) AKT1, ATR, BUB1B, CDC7, CHUK, CIT, EPHA3, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GRK6, HASPIN, MAP3K7, PBK, PI4K2B, PLK1, PRKDC, RPS6KA1, STRADB, TRIM28, TTK, VRK1
Non-kinase Count 1112
label pval fdr signature geneset overlap hits
KEGG_PYRIMIDINE_METABOLISM 0 0e+00 1139 98 29 CAD,DHODH,DTYMK,DUT,ENTPD6,NME1,PNPT1,POLA1,POLA2,POLD1,POLE2,POLE3,POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K,PRIM1,RRM2,TK1,TYMS,UMPS
KEGG_DNA_REPLICATION 0 0e+00 1139 36 20 DNA2,FEN1,LIG1,MCM2,MCM5,MCM6,POLA1,POLA2,POLD1,POLE2,POLE3,PRIM1,RFC2,RFC3,RFC4,RFC5,RNASEH1,RPA1,RPA3,SSBP1
KEGG_PURINE_METABOLISM 0 0e+00 1139 159 34 ADCY3,ENTPD2,ENTPD6,GART,HPRT1,IMPDH1,NME1,NUDT5,PAICS,PDE4A,PDE7A,PNPT1,POLA1,POLA2,POLD1,POLE2,POLE3,POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K,PPAT,PRIM1,PRPS1,PRPS2,RRM2
KEGG_CELL_CYCLE 0 0e+00 1139 124 29 ANAPC1,ANAPC10,ANAPC4,ATR,BUB1B,BUB3,CCNE1,CDC20,CDC45,CDC7,DBF4,E2F4,HDAC2,MAD2L1,MCM2,MCM5,MCM6,ORC1,ORC2,ORC5,PKMYT1,PLK1,PRKDC,PTTG1,SKP2,SMC1A,TFDP1,TGFB2,TTK
KEGG_SPLICEOSOME 0 0e+00 1139 127 28 AQR,CDC5L,DHX15,EFTUD2,HNRNPC,LSM3,LSM6,LSM7,NCBP1,PPIH,PPIL1,PRPF19,PRPF38B,PRPF4,PRPF40A,SF3B4,SNRNP200,SNRNP40,SNRNP70,SNRPC,SNRPD1,SNRPD3,SNRPF,SNRPG,SRSF10,SRSF9,THOC3,TXNL4A
KEGG_MISMATCH_REPAIR 0 0e+00 1139 23 13 EXO1,LIG1,MLH1,MLH3,MSH6,POLD1,RFC2,RFC3,RFC4,RFC5,RPA1,RPA3,SSBP1
KEGG_HOMOLOGOUS_RECOMBINATION 0 0e+00 1139 28 12 BLM,EME1,MRE11,POLD1,RAD51C,RAD54B,RPA1,RPA3,SSBP1,TOP3B,XRCC2,XRCC3
KEGG_RNA_POLYMERASE 0 0e+00 1139 29 12 POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K
KEGG_BASE_EXCISION_REPAIR 0 0e+00 1139 35 12 APEX1,APEX2,FEN1,HMGB1,LIG1,NEIL2,NTHL1,PARP1,POLD1,POLE2,POLE3,TDG
KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 1e-07 1139 44 11 GTF2H3,LIG1,POLD1,POLE2,POLE3,RFC2,RFC3,RFC4,RFC5,RPA1,RPA3
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2e-07 1139 134 17 ANAPC1,ANAPC10,ANAPC4,BRCA1,CDC20,CUL2,FANCL,PRPF19,SAE1,SKP2,UBE2G2,UBE2L3,UBE2N,UBE2NL,UBE2S,UBE3C,VHL
KEGG_OOCYTE_MEIOSIS 0 6e-07 1139 112 15 ADCY3,ANAPC1,ANAPC10,ANAPC4,CCNE1,CDC20,FBXO5,MAD2L1,PKMYT1,PLK1,PPP1CC,PTTG1,RPS6KA1,SGO1,SMC1A

Num: 16 (Pathways: 1 DK: 4)

gene_type info
Dark Kinase (4) OBSCN, STK17A, STK17B, TSSK4
Light Kinase (14) BLVRA, GRK3, GRK4, MAP3K1, MAPK13, MET, MYO3B, NTRK3, PDK3, PIK3CD, PRKCI, SNRK, SYK, TNIK
Non-kinase Count 379
label pval fdr signature geneset overlap hits
KEGG_ENDOCYTOSIS 0 0 397 181 14 ACAP1,ARFGAP1,CBLB,CHMP2B,CHMP4C,EHD4,GRK3,GRK4,HLA-B,LDLR,MET,PRKCI,SH3GL3,VPS37B

Num: 8 (Pathways: 3 DK: 2)

gene_type info
Dark Kinase (2) MKNK2, NIM1K
Light Kinase (5) DYRK1A, MAP3K2, PDK1, PRKAA2, TEC
Non-kinase Count 390
label pval fdr signature geneset overlap hits
KEGG_GLYCOLYSIS_GLUCONEOGENESIS 0.0e+00 3.0e-07 397 62 9 ALDOA,ENO1,ENO2,GAPDH,GPI,LDHA,PGK1,PKM,TPI1
KEGG_PENTOSE_PHOSPHATE_PATHWAY 2.2e-06 2.0e-04 397 27 5 ALDOA,GPI,PGD,TALDO1,TKT
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 7.1e-06 4.4e-04 397 34 5 AKR1B1,AKR1B10,ALDOA,PFKFB4,TPI1

Num: 13 (Pathways: 0 DK: 2)

gene_type info
Dark Kinase (2) BCKDK, TBCK
Light Kinase (1) DDR1
Non-kinase Count 118
label pval fdr signature geneset overlap hits

Num: 15 (Pathways: 0 DK: 2)

gene_type info
Dark Kinase (2) PI4KA, RNASEL
Light Kinase (16) BMPR2, CDK5, EPHA10, EPHB4, FPGT-TNNI3K, JAK3, MAP2K4, PDGFRB, PDK2, PIK3C2A, PRKD3, PTK7, ROCK1, SPEG, SRC, TRIM24
Non-kinase Count 435
label pval fdr signature geneset overlap hits

Num: 17 (Pathways: 17 DK: 2)

gene_type info
Dark Kinase (2) PKN3, TSSK3
Light Kinase (14) AKT2, BMPR1A, DGKH, DGKI, HIPK2, IRAK1, MAP3K3, MAP4K3, PDPK1, PIK3CA, RIPK1, SIK2, TRRAP, WNK1
Non-kinase Count 276
label pval fdr signature geneset overlap hits
KEGG_ENDOMETRIAL_CANCER 0.0e+00 2.8e-06 292 52 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_NON_SMALL_CELL_LUNG_CANCER 0.0e+00 2.8e-06 292 54 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_PROSTATE_CANCER 1.0e-07 2.9e-06 292 89 8 AKT2,EP300,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 1.0e-07 2.9e-06 292 126 9 AKT2,HRAS,IRAK1,MAP3K3,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_INSULIN_SIGNALING_PATHWAY 1.0e-07 4.8e-06 292 137 9 AKT2,HRAS,NRAS,PDPK1,PHKB,PIK3CA,PRKAR1A,SOS1,SOS2
KEGG_RENAL_CELL_CARCINOMA 2.0e-07 5.8e-06 292 70 7 AKT2,EP300,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 4.0e-07 1.2e-05 292 79 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_ACUTE_MYELOID_LEUKEMIA 1.1e-06 2.5e-05 292 57 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_GLIOMA 2.3e-06 4.8e-05 292 65 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_FOCAL_ADHESION 3.0e-06 5.5e-05 292 199 9 AKT2,HRAS,ITGA10,PARVA,PDPK1,PIK3CA,SOS1,SOS2,ZYX
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 3.6e-06 6.1e-05 292 108 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_CHRONIC_MYELOID_LEUKEMIA 4.6e-06 7.2e-05 292 73 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 5.4e-06 7.7e-05 292 75 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_ERBB_SIGNALING_PATHWAY 1.3e-05 1.7e-04 292 87 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_GNRH_SIGNALING_PATHWAY 3.0e-05 3.7e-04 292 101 6 HRAS,MAP3K3,MMP14,NRAS,SOS1,SOS2
KEGG_JAK_STAT_SIGNALING_PATHWAY 3.8e-05 4.4e-04 292 155 7 AKT2,EP300,IL13RA1,PIK3CA,SOS1,SOS2,STAT6
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 4.0e-05 4.4e-04 292 213 8 ARPC1B,ARPC4,HRAS,ITGA10,NRAS,PIK3CA,SOS1,SOS2

Num: 19 (Pathways: 4 DK: 2)

gene_type info
Dark Kinase (2) CSNK2A3, PRKACB
Light Kinase (3) DGKQ, ERBB3, RPS6KA6
Non-kinase Count 370
label pval fdr signature geneset overlap hits
KEGG_ALZHEIMERS_DISEASE 0 0e+00 375 165 14 ATP5F1C,ATP5F1E,ATP5PD,CALM1,COX7A2,COX7C,FADD,NDUFA4L2,NDUFB1,NDUFB5,PPP3CB,UQCR11,UQCRB,UQCRQ
KEGG_HUNTINGTONS_DISEASE 0 0e+00 375 180 14 ATP5F1C,ATP5F1E,ATP5PD,COX7A2,COX7C,CREB3L2,DNAL4,NDUFA4L2,NDUFB1,NDUFB5,POLR2E,UQCR11,UQCRB,UQCRQ
KEGG_OXIDATIVE_PHOSPHORYLATION 0 0e+00 375 131 12 ATP5F1C,ATP5F1E,ATP5PD,ATP6V0D1,COX7A2,COX7C,NDUFA4L2,NDUFB1,NDUFB5,UQCR11,UQCRB,UQCRQ
KEGG_PARKINSONS_DISEASE 0 2e-07 375 128 11 ATP5F1C,ATP5F1E,ATP5PD,COX7A2,COX7C,NDUFA4L2,NDUFB1,NDUFB5,UQCR11,UQCRB,UQCRQ

Num: 20 (Pathways: 0 DK: 2)

gene_type info
Dark Kinase (2) ALPK2, PXK
Light Kinase (4) BRDT, ERN1, MAK, PRKCE
Non-kinase Count 248
label pval fdr signature geneset overlap hits

Num: 6 (Pathways: 0 DK: 1)

gene_type info
Dark Kinase (1) CDK14
Light Kinase (3) AATK, OXSR1, RIPK4
Non-kinase Count 171
label pval fdr signature geneset overlap hits